**Section 3 Cancer Therapies 137** Chapter 6 **An Overview of Cancer Treatment Modalities 139** Zaigham Abbas and Sakina Rehman Chapter 7 **Biomarker-Based Targeted Therapeutics 159** Shainan Hora, Amit Kumar Pandey and Sudhakar Jha Chapter 8 **Targeting the Ubiquitin Proteasome System in Cancer 203** Nishi Kumari, Kwok Kin Lee and Sudhakar Jha

Preface

ble knowledge resource for target readers.

Neoplasm represents the abnormal growth of tissue that arises due to rapid and unregulat‐ ed proliferation of cells, which lacks coordination with the surrounding tissues. This uncon‐ trolled growth eventually turns out to be a mass or a tumor if it persists in the body. The neoplasm can be noncancerous (benign), precancerous (premalignant), or cancerous (malig‐ nant) depending on the severity of disease. Another way of classifying tumors is according to the tissues and cells involved. The development of cancer is a multistep process where normal cells acquire enhanced capacity of proliferation, survival, invasion, and metastasis as a consequence of progressive series of genetic modifications, which accumulate over a lon‐ ger period of time. The clonal expansion of such transformed cells results in the progression of cancer. In the past several years, tremendous advances have been made in the knowledge of development, diagnosis, and treatment of cancer. This book encompasses the significant advances in the understanding of basic biology, diagnosis, and treatment of some important cancer types. Overall, the book is divided into three sections. The first section summarizes the clinical and pathological features, imaging characteristics, therapeutic approaches, as well as genomic and molecular aberrations associated with colorectal, central nervous sys‐ tem, and uterine neoplasms. The second section includes a comprehensive discussion on cancer metastasis as well as some other novel cancer-related mechanisms, for instance, glu‐ cose metabolism and nonalcoholic lipid accumulation. The third section describes various approaches of generalized and targeted cancer therapies. All chapters of this book are clear‐ ly written with a considerable detail relating to each of the issues addressed by the authors. Each of the chapters provides a rationale for the topic being covered and some general de‐ tails about tumors where applicable. The citations used in the chapters are comprehensively referred to, which adds depth to the information being presented. Undoubtedly, this book would be an excellent resource for anyone who wants to learn the basics about multiple as‐ pects of tumor biology and management practices. On the whole, it may prove to be a valua‐

**Dr. Hafiz Naveed Shahzad**

School of Biological Sciences University of the Punjab

Assistant Professor

Lahore, Pakistan

## Preface

**Section 3 Cancer Therapies 137**

**VI** Contents

Chapter 6 **An Overview of Cancer Treatment Modalities 139** Zaigham Abbas and Sakina Rehman

Shainan Hora, Amit Kumar Pandey and Sudhakar Jha

Chapter 8 **Targeting the Ubiquitin Proteasome System in Cancer 203** Nishi Kumari, Kwok Kin Lee and Sudhakar Jha

Chapter 7 **Biomarker-Based Targeted Therapeutics 159**

Neoplasm represents the abnormal growth of tissue that arises due to rapid and unregulat‐ ed proliferation of cells, which lacks coordination with the surrounding tissues. This uncon‐ trolled growth eventually turns out to be a mass or a tumor if it persists in the body. The neoplasm can be noncancerous (benign), precancerous (premalignant), or cancerous (malig‐ nant) depending on the severity of disease. Another way of classifying tumors is according to the tissues and cells involved. The development of cancer is a multistep process where normal cells acquire enhanced capacity of proliferation, survival, invasion, and metastasis as a consequence of progressive series of genetic modifications, which accumulate over a lon‐ ger period of time. The clonal expansion of such transformed cells results in the progression of cancer. In the past several years, tremendous advances have been made in the knowledge of development, diagnosis, and treatment of cancer. This book encompasses the significant advances in the understanding of basic biology, diagnosis, and treatment of some important cancer types. Overall, the book is divided into three sections. The first section summarizes the clinical and pathological features, imaging characteristics, therapeutic approaches, as well as genomic and molecular aberrations associated with colorectal, central nervous sys‐ tem, and uterine neoplasms. The second section includes a comprehensive discussion on cancer metastasis as well as some other novel cancer-related mechanisms, for instance, glu‐ cose metabolism and nonalcoholic lipid accumulation. The third section describes various approaches of generalized and targeted cancer therapies. All chapters of this book are clear‐ ly written with a considerable detail relating to each of the issues addressed by the authors. Each of the chapters provides a rationale for the topic being covered and some general de‐ tails about tumors where applicable. The citations used in the chapters are comprehensively referred to, which adds depth to the information being presented. Undoubtedly, this book would be an excellent resource for anyone who wants to learn the basics about multiple as‐ pects of tumor biology and management practices. On the whole, it may prove to be a valua‐ ble knowledge resource for target readers.

**Dr. Hafiz Naveed Shahzad**

Assistant Professor School of Biological Sciences University of the Punjab Lahore, Pakistan

**Section 1**

**Various Types of Cancer**
