**13.2.** *Artemisia afra* **(Jacq. Ex. Willd), 'African wormwood'**

*A. afra* has been used for coughs, colic, fever, loss of appetite, earache, headache, malaria and intestinal worms [51]. Several studies have been conducted to substantiate the traditional use of this herb; it is also being investigated in diseases like diabetes, cancer and respiratory diseases among others [51].

In acute toxicity studies of aqueous extract of *A. afra* in mice administered doses (i.p., 1.5–5.5 g/kg) caused a regular dose-dependent increase in the death rate and also of general adverse behavior, but with single doses (2–24 g/kg) administered orally, the previous observed increases in the incidence of death rate and adverse general behavior that did not show were doseindependent. The route of administration, acute intraperitoneal and oral doses, showed LD50 of 2.45 and 8.96 g/kg, respectively [51].
