*13.2.1. Animal toxicity*

In the chronic studies, rats administered *A. afra* aqueous extract (0.1 or 1 g/kg/day) survived the 3 months of daily dosing with LD50 greater than 1 g/kg. No significant changes were observed in the general behavior, hematological and biochemical parameters except for a transient decrease in aspartate aminotransaminase (AST) activity. No significant changes were observed in the organ weights and histopathological results showed no morphological alterations. High doses of the extract were also shown to be hepatoprotective. The aqueous extract of *A. afra* has been shown to be nontoxic in acute use and low chronic toxicity potential in rodent models [51].
