**Author details**

the field of ozone therapy over the last 130 years. It has demonstrated interesting therapeutic results. The biological effects of ozone include antimicrobial activity (antibacterial, antiviral,

sible applications of the Bioxoil™ products, already distributed in pharmacies and herbalist's shops, have been described; its production line includes five different products characterized by different concentrations of ozonides such as to allow the use for the most varied skin affections. Bioxoil with the highest content of ozonides is indicated for the treatment of bedsores at first and second stages, thanks to its anti-inflammatory and cicatrizing properties, Bioxoil with medium concentrations, but different from each other, is indicated for the treatment of herpes labialis, mycosis, and onychomycosis and for acne due to its antimicrobial action. Finally, Bioxoil with the lowest ozonide content is indicated to soothe contact or allergic irritations. The exceptional usability of the product and its completely natural origin offers a vast

metabolism [59]. In this chapter, the pos-

and antifungal), antalgic action, and improved O<sup>2</sup>

ROS reactive oxygen species

LDL low density lipoprotein

3,4-DHPEA-EDA 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde

p-HPEA-EDA 2-(4-hydroxyphenyl)ethyl (4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate

IsoPs F2-isoprostanes COX cyclooxygenase

3,4-DHPEA hydroxytyrosol

COX-1 cyclooxygenase 1 COX-2 cyclooxygenase 2 PI peroxide index AI acidity index

SG stratum germinativum

SS stratum spinosum SGR stratum granulosum

SC stratum corneum

GSH glutathione

LOP lipid oxidation

MIC minimal inhibitory concentration

market.

240 Herbal Medicine

**Abbreviations**

Elisabetta Carata<sup>1</sup> , Bernardetta Anna Tenuzzo<sup>1</sup> and Luciana Dini1,2\*

\*Address all correspondence to: luciana.dini@unisalento.it

