A. Annex VI: List of UV filters allowed in cosmetic products according to EU regulation [11]

List of sunscreen ingredients approved in the USA as presented in the "Sunscreen Drug Products for Over-the-Counter Human Use" monograph (21 CFR 352.10) [12].



Language School, Swieqi, Malta) and Luigi Mastroianni (State Language High School "Giosuè

A. Annex VI: List of UV filters allowed in cosmetic products according

Products for Over-the-Counter Human Use" monograph (21 CFR 352.10) [12].

Chemical name Name of common ingredient

4-Aminobenzoic acid PABA 5%

2-Hydroxy-4-methoxybenzophenone/oxybenzone Benzophenone-3 10%

alpha-(2-Oxoborn-3-ylidene)-toluene-4-sulphonic acid and its salts Benzylidene camphor sulfonic

2-Cyano-3,3-diphenyl acrylic acid, 2-ethylhexyl ester/octocrylene Octocrylene 10% (as acid)

2-Ethylhexyl 4-methoxycinnamate/octinoxate Ethylhexyl methoxycinnamate 10% Ethoxylated ethyl-4-aminobenzoate PEG-25 PABA 10% Isopentyl-4-methoxycinnamate/amiloxate Isoamyl p-methoxycinnamate 10%

3-(4-Methylbenzylidene)-d1 camphor/enzacamene 4-Methylbenzylidene` camphor 4% 3-Benzylidene camphor 3-Benzylidene camphor 2%

List of sunscreen ingredients approved in the USA as presented in the "Sunscreen Drug

glossary

methosulfate

sulfonic acid

acid

acid


Camphor benzalkonium

Phenylbenzimidazole sulfonic

Terephthalylidene dicamphor

Polyacrylamidomethyl benzylidene camphor

Butyl methoxydibenzoylmethane 5%

Drometrizole trisiloxane 15%

Diethylhexyl butamido triazine 10%

Homosalate 10%

Maximum concentration in ready-for-use preparation

8% (as acid)

10% (as acid)

6% (as acid)

6%

6%

Carducci" Ferrara, Italy) for their careful English revision.

N,N,N-Trimethyl-4-(2-oxoborn-3-ylidenemethyl) anilinium methyl

2-Phenylbenzimidazole-5-sulfonic acid and its potassium, sodium,


1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione/

Polymer of N-{(2 and 4)-[(2-oxoborn-3-ylidene)methyl]benzyl}


Phenol,2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3, 3-tetramethyl-1-(trimethylsilyl)oxy)-disiloxanyl)propyl)

Benzoic acid, 4,4-((6-((4-(((1,1-dimethylethyl)amino)carbonyl) phenyl)amino)-1,3,5-triazine-2,4-diyl)diimino)bis-, bis

Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester/

and triethanolamine salts/ensulizole

to EU regulation [11]

56 Herbal Medicine

sulfate

3,3<sup>0</sup>

homosalate

avobenzone

acrylamide

2,4,6-Trianilino-(p-carbo-2<sup>0</sup>

(2-ethylhexyl) ester/iscotrizinol (USAN)



[6] Thiele JJ, Dreher F, Packer L. Antioxidant defence systems in skin. In: Elsner P, Malbach H, Rougier A, editors. Drugs vs Cosmetics: Cosmeceuticals? New York: Marcel Dekker; 2000.

Guidelines for the Development of Herbal-Based Sunscreen

http://dx.doi.org/10.5772/intechopen.72712

59

[7] Svobodovà A, Psotová J, Walterová D. Natural phenolics in the prevention of UVinduced skin damage. A review. Biomedical Papers. 2003;147:137-145. DOI: 10.5507/bp.

[8] Saewan N, Jimtaisong A. Photoprotection of natural flavonoids. Journal of Applied

[9] Vayalil PK, Elmets CA, Katiyar SK. Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin. Carcino-

[10] Bino A, Baldisserotto A, Scalambra E, Dissette V, Vedaldi DE, Salvador A, Durini E, Manfredini S, Vertuani S. Design, synthesis and biological evaluation of novel hydroxyphenyl-1H-benzimidazoles as radical scavengers and UV-protective agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):527-537. DOI: 10.1080/14756366.

[11] Naranyanan DL, Saladi RN, Fox JL. Ultraviolet radiation and skin cancer. International Journal of Dermatology. 2010;49:978-986. DOI: 10.1111/j.1365-4632.2010.04474.x

[12] Clydesdale GJ, Dandie GW, Muller HK. Ultraviolet light induced injury: Immunological and inflammatory effects. Immunology and Cell Biology. 2001;79:547-568. DOI: 10.1046/

[13] Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms. Archives of Dermatological Research. 2010;302:

[14] Cvetkovska AD, Manfredini S, Ziosi P, Molesini S, Dissette V, Magri I, Scapoli C, Carrieri A, Durini E, Vertuani S. Factors affecting SPF in vitro measurement and correlation with in vivo results. International Journal of Cosmetic Science. 2017;39:310-319. DOI: 10.1111/

[15] Perea SE. Solar filters: A strategy of photoprotection. Applied Photochemistry. 2016;92:

[16] Regulation (EC) N. 1223/2009 of the European Parliament and of the council of 30 November 2009 on cosmetic product [Internet]. 2009. Available from: http://eur-lex.europa.eu/legalcontent/EN/TXT/?uri=CELEX:02009R1223-20160812&from=EN [Accessed: 01-08-2017] [17] Rulemaking history for OTC Sunscreen Drug Products. Available from: https://www.fda.gov/ Drugs/DevelopmentApprovalProcess/DevelopmentResources/Over-the-CounterOTCDrugs/

StatusofOTCRulemakings/ucm072134.htm#timeandexten [Accessed: 01-08-2017]

Pharmaceutical Science. 2013;3:129-141. DOI: 10.7324/JAPS.2013.3923

genesis. 2003;24:927-936. DOI: 10.1093/carcin/bgg025

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71-83. DOI: 10.1007/s00403-009-1001-3

459-478. DOI: 10.1007/978-3-319-31671-0\_11
