*13.4.1. Animal toxicity*

*C. procera* has been shown to adversely affect early and late pregnancy in rats [70]. Acute toxicity studies in mice, however, showed no significant change in the hematological parameters. Behavioral changes, symptoms of toxicity and mortality were absent during the 24-h duration of the experiment. In the 3-month chronic toxicity study with 100 mg/kg, body weight per day, a 50% mortality of the animals was recorded. No significant changes in the hematological parameters were observed. This study suggested a safe use of the plant in single high dose but a serious health hazard may ensue with prolong use.
