Contents

### **Preface XI**


Preface

been written by the experienced authors.

Blood is a vital fluid in the human body. It has important cells and plasma as its constituents. One important type of cell is "platelet" or thrombocyte. Platelet has various functions such as coagulation and immunology. The number and quality of platelet cells should be optimum for normal hemostasis. Low platelet count or "thrombocytopenia" interferes with the normal equilibrium. It gives me immense pleasure to edit a book on this topic. We do not have enough books/publications to do justice to this important topic. Only the optimum manage‐ ment of this condition can affect the clinical outcome of patients with thrombocytopenia.

Science is constantly progressing and it never stops. New concepts are always forthcoming. This book covers the new literature and is quite up to date. State-of-the-art chapters have

Dengue is a common disease in various parts of the world. Patients can recover without any complication, but some develop severe thrombocytopenia. Immunopathogenesis of throm‐ bocytopenia in patients with dengue must be well understood to provide adequate manage‐ ment. This book provides details about this aspect of thrombocytopenia. It also provides comprehensive studies about thrombocytopenia in antiphospholipid syndrome (APS) and management of thrombocytopenia in APS. The latest literature has been provided by the authors. In these days of organ transplantation, one should know the mechanism of throm‐ bocytopenia in patients with chronic liver diseases and liver transplant, which is discussed in light of the latest references. Interferon had been a primary therapy for diseases such as HCV, CML, multiple sclerosis, etc., for quite a long time. Interferon can induce thrombotic microangiopathy in many such patients. This observation along with later studies has help‐ ed us to understand immunobiology and its consequent application in immunomodulating therapeutics. This book "Thrombocytopenia" shall provide the latest literature on the topic. Heparin, an anticoagulant used quite often, is also associated with thrombocytopenia. The mechanism of thrombocytopenia, whether unfractionated or LMWH, has to be used. Such

studies with latest observations have been included in a chapter on this topic.

serve as a guide to students, scientists and clinicians working in the field.

Thus, it can be fairly concluded that the book "Thrombocytopenia" covers important topics and provides a good insight into the latest literature about the topic. I sincerely hope it will

> **Dr. Pankaj Abrol** Professor and Head Department of Pediatrics

Gurgaon (Haryana), India

SGT Medical College Hospital & Research Institute
