**4. Conclusion**

Platelets are cellular fragments derived from hematopoietic precursors megakaryocytes, primarily associated with coagulation and hemostasis and also with inflammation, immune response, angiogenesis, and extracellular matrix synthesis. In fact, platelets contain several preformed molecules, large amounts of mRNA, and the packaged translational process required to synthesize new biologically active proteins, including growth factors, cytokines, and chemokines. Platelets are one of the major cell populations affected in dengue, once both thrombocytopenia and platelet dysfunction are common manifestations of infection and strongly related to the patient's clinical outcome. Dysfunction of platelets is implicated in prothrombotic complications associated with severe cases of dengue. Thus, platelets could be considered cells that are active against the anti-DENV immune response, and therefore, thrombocytopenia is a key prognostic factor in the immunopathogenesis of dengue.
