Contents

#### **Preface XI**


#### **Section 4 Drug Resistance and Potential Treatments 119**

Chapter 8 **Molecular Interaction Between the Microenvironment and FLT3/ITD+ AML Cells Leading to the Refractory Phenotype 121** Seiji Fukuda, Tomohiro Hirade, Mariko Abe, Takeshi Taketani and Chie Onishi

Preface

are discussed:

their tremendous efforts.

viders, patients, and their families.

spectives are now considered for patients.

1. Myeloid Leukemia: Multifaceted Disease

2. Pathogenicity and Diagnostic 3. Genetic and Epigenetic Regulations 4. Drug Resistance and Potential Treatments

Myeloid leukemia is a multifaceted disease, regrouping a variety of myeloid disorders. Re‐ cently, important progress has been made in both its diagnosis and treatment. However, some forms are curable and others are treatable but rarely curable. New therapeutic per‐

The aim of our book is to cover key aspects of myeloid leukemia, including its diagnosis and current treatments and the challenges ahead. To apprehend this complex disease, critical molecular and cellular mechanisms including the role of the tumor microenvironment are highlighted. Important molecular targets are described and new therapeutic considerations

The publication of this book was made possible by coordinated efforts and collaborations from many experts in the field. We thank all the contributors for their valuable work and

We are confident that this book will provide valuable insights into myeloid leukemia at dif‐ ferent levels. In the meantime, we trust it will bring answers and hope for health care pro‐

**Ahmed Lasfar**

Member of New Jersey Cancer Institute Principal investigator and Faculty member Department of Pharmacology and Toxicology

Piscataway, New Jersey, United States

Ernest Mario School of Pharmacy, Rutgers University

