**SERS-Based Sensitive Detection of Organophosphorus Nerve Agents** SERS-Based Sensitive Detection of Organophosphorus

DOI: 10.5772/intechopen.72630

Qian Zhao, Guangqiang Liu and Weiping Cai

Additional information is available at the end of the chapter Qian Zhao, Guangqiang Liu and Weiping Cai

http://dx.doi.org/10.5772/intechopen.72630 Additional information is available at the end of the chapter

#### Abstract

Nerve Agents

[214] Blum C, Schmid T, Opilik L, Weidmann S, Fagerer SR, Zenobi R. Understanding tipenhanced Raman spectra of biological molecules: A combined Raman SERS and TERS

[215] Opilik L, Bauer T, Schmid T, Stadler J, Zenobi R. Nanoscale chemical imaging of segregated lipid domains using tip-enhanced Raman spectroscopy. Physical Chemistry

[216] Kneipp J, Kneipp H, Rajadurai A, Redmond RW, Kneipp K. Optical probing and imaging of live cells using SERS labels. Journal of Raman Specroscopy. 2009;**40**:1-5

[217] Chao J-I, Perevedentseva E, Chung PH, Liu KK, Cheng CY, Chang CC, Cheng CL. Nanometer-sized diamond particle as a probe for biolabeling. Biophysical Journal.

[218] Henry A-I, Sharma B, Cardinal MF, Kurouski D, Van Duyne RP. Surface-enhanced raman spectroscopy biosensing: In vivo diagnostics and multimodal imaging. Ana-

[219] Bodelón G, Montes-García V, Fernández-López C, Pastoriza-Santos I, Pérez-Juste J, Liz-Marzán LM. Bioimaging: Au@pNIPAM SERRS ags for multiplex immunophenotyping

[220] Mallia R, Veilleux I, Wilson BC, McVeigh P. Filter-based method for background removal in high-sensitivity wide-field-surface-enhanced Raman scattering imaging

[221] Keren S, Zavaleta C, Cheng Z, de la Zerda A, Gheysens O, Gambhir SS. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proceedings of

cellular receptors and imaging tumor cells. Small. 2015;**11**:4220-4220

in vivo. Journal of Biomedical Optics. 2012;**17**:076017

the National Academy of Sciences. 2008;**105**:5844-5849

study. Journal of Raman Specroscopy. 2012;**43**:1895-1904

Chemical Physics. 2011;**13**:9978-9981

lytical Chemistry. 2016;**88**:6638-6647

2007;**93**:2199-2208

126 Raman Spectroscopy

Organophosphorus nerve agents, such as sarin, tabun, cyclosarin and soman, belong to the most toxic substances. So, it is very important to quickly detect it in trace-level and on-site or portable way. But, both fast and trace detections have been expected because current techniques are of low sensitivity or of poor selectivity and are time-consuming. The surface-enhanced Raman scattering (SERS)-based detection could be a suitable and effective method. However, the organophosphorus nerve agents only very weakly interact with highly SERS-activated noble metal substrates and are hardly adsorbed on them. In this case, it is difficult to detect such molecules, with reproducible or quantitative measurements and trace level, by the normal SERS technique. Recently, there have been some works on the SERS-based detection of the organophosphorus molecules. In this chapter, we introduce the main progresses in this field, including (1) the thin water film confinement and evaporation concentrating strategy and (2) the surface modification and amidation reaction. These works provide new ways for highly efficient SERS-based detection of the organophosphorus nerve agents and some other target molecules that weakly interact with the coin metal substrates.

Keywords: SERS-based sensitive detection, organophosphorus nerve agents, thin water film confinement, concentrating-enhanced Raman scattering effect, surface modification, amidation reaction
