**Author details**

Catherine Bardelle<sup>1</sup> \*, Vincent Sauzeau2 , Mark B. Carter<sup>3</sup> , Zhaoping Liu<sup>3</sup> , Gervaise Loirand<sup>2</sup> and David Murray1

[12] Surviladze Z et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. Journal of Biomolecular Screening.

High Throughput Screen for Inhibitors of Rac1 GTPase by Flow Cytometry

http://dx.doi.org/10.5772/intechopen.71074

61

[13] Surviladze Z et al. High throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors. Methods in Molecular Biology. 2012;**827**:253-270

[14] Murray D, Wigglesworth M. Chapter 1 HTS methods: Assay design and optimisation. In: High Throughput Screening Methods: Evolution and Refinement. London: The Royal

[15] Wigglesworth MJ et al. Increasing the delivery of next generation therapeutics from high throughput screening libraries. Current Opinion in Chemical Biology. 2015;**26**:104-110

[16] Malo N et al. Statistical practice in high-throughput screening data analysis. Nature

[17] Zhang JH et al. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. Journal of Biomolecular Screening. 1999;**4**(2):67-73

2010;**15**(1):10-20

Society of Chemistry; 2017. p. 1-15

Biotechnology. 2006;**24**(2):167-175

