Contents

### **Preface XI**


### **Section 3 New Approaches in the Treatment of Salivary Gland Diseases 103**

Chapter 7 **Salivary Effects of Facial Vibrotactile Stimulation in Patients with Sjogren's Syndrome and Poor Salivation 105** Koichiro Ueda, Kanako Gora, Masaru Yamaoka, Takako Sato, Kimiko Abe, Enri Nakayama, Mituyasu Sato, Yumiko Tunoda, Sumiko Akatuka, Sayaka Fukui, Akinari Hayashi, Teruyuki Hirai, Sayako Ohnishi, Mayumi Hayata and Hisao Hiraba

Preface

ing this book happen.

more easily accepted by clinicians and patients.

Saliva is a complex fluid that maintains oral health and possesses important functions in lubrication, digestion, taste perception and speech. Moreover, saliva is a potential noninva‐ sive diagnostic fluid, which provides valuable diagnostic information for detecting numer‐ ous diseases. Thanks to the advances in diagnostic methods, the number of studies using salivary analysis in the diagnosis of various diseases and conditions has increased tremen‐ dously. As evidence from recent research accumulates, salivary diagnostics will become

*Salivary Glands - New Approaches in Diagnostics and Treatment* is a comprehensive reference, which brings together information on salivary secretion and its disorders, as well as novel diagnostic methods for numerous diseases with the use of salivary secretions, and new tech‐ niques in the treatment of salivary diseases. Therefore, this book contains a source of informa‐ tion for a diverse audience, such as researchers of basic science and clinicians of surgical and medical sciences, including dentists, oral biologists, experimental biologists, molecular biolo‐ gists, oncologists, radiologists, oral and maxillofacial surgeons, and otorhinolaryngologists. In the first three chapters of the book, a basic understanding of salivary secretion is provid‐ ed along with a description and management of conditions that decrease or increase the amount of saliva. The next section of the book introduces the reader to salivary diagnostics, a new diagnostic approach that has the potential to reach clinical practice in the near future for the early detection, diagnosis, and monitoring of many diseases, such as cancer, human papillomavirus infections, dental problems, diabetes, heart diseases, Sjögren's syndrome, and even neurological and psychiatric disorders. Afterwards, the proteomics of saliva are described in detail. Next, scintigraphic techniques for the functional diagnosis of salivary diseases and for distinguishing salivary tumors are discussed. The last two chapters de‐ scribe a combined endoscopic procedure used in recent years in the treatment of sialolithia‐

sis and a novel method, facial vibrotactile stimulation, for the increase of salivation.

I would like to sincerely thank my husband Erkan Güvenç for his patience, my mother Emel Adadan who was always beside me whenever she was needed, and our nanny Ellie Mikrut who took great care of my dearest Kaan for sacrificing their time and supporting me in mak‐

**Işıl Adadan Güvenç, MD**

Izmir, Turkey

Cigli Regional Education Hospital

#### Chapter 8 **Combined Approaches in Sialolithiasis of Major Salivary Glands 117** Iordanis Konstantinidis, Angelos Chatziavramidis and Ioannis

Iakovou
