**Approach to Diagnosis of Salivary Gland Disease from Nuclear Medicine Images Nuclear Medicine Images**

**Approach to Diagnosis of Salivary Gland Disease from** 

DOI: 10.5772/intechopen.70622

Michihiro Nakayama, Atsutaka Okizaki, Kaori Nakajima and Koji Takahashi Kaori Nakajima and Koji Takahashi Additional information is available at the end of the chapter

Michihiro Nakayama, Atsutaka Okizaki,

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.70622

#### **Abstract**

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Nuclear medicine images can help in the diagnosis and assessment of some salivary disorders. 99mTcO4−, gallium-67-citrate scintigraphy will be an indication of the function of salivary gland together and it will be used for the diffuse diseases such as sialadenitis, Sjögren's syndrome, sarcoidosis, glossopharyngeal paralysis, and irradiation. It is also effective for distinguishing benign tumor legion with Warthin's tumor and others. Moreover, fluorodeoxyglucose positron emission tomography (FDG-PET) is an indispensable modality for determining the localization, focal lesions, and staging of many malignant tumors, the fluorodeoxyglucose (FDG) accumulation is visually and semiquantitatively assessed using the standardized uptake value (SUV), which is the ratio of uptake to the injected dose per unit body weight. Also for radioactive iodine therapy, attention should be paid to adverse reactions. It is important to note that acute/chronic salivary gland disorders are associated with radioiodine therapy for the treatment of postoperative thyroid cancer. Coordination among healthcare providers including nurses, radiological technologists, and doctors of all departments involved in treatment is important for achieving effective outcomes.

**Keywords:** scintigraphy, 99mTcO4−, SPECT, FDG-PET, salivary gland disorders

### **1. Introduction**

Radionuclide imaging, commonly used for the diagnosis of salivary gland diseases, consists of salivary scintigraphy using 99mTcO4−, gallium-67-citrate (67Ga) scintigraphy in inflammation, and fluorodeoxyglucose positron emission tomography (FDG-PET). It is important to note that acute/chronic salivary gland disorders are associated with radioiodine therapy for the treatment of postoperative thyroid cancer.

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