**5. Autoantibodies in course of pSS—summary**

In the current pSS criteria, only anti-SS-A/Ro antibodies are taken into account as the most sensitive and specific for pSS diagnosis. Still, the multisymptom picture of this rheumatic disease compels the search for other immunologic markers of at least equal prognostic importance.


**Table 4.** Antibodies in pSS and their association with clinical manifestation.

The occurrence of some of the identified antibodies has been associated with the specific clinical features such as interstitial lung disease, increased eye dryness, increased risk of nephrolithiasis and tubular distal acidosis or MALT lymphomas. In **Table 4**, autoantibodies frequently occurring in pSS and their association with clinical manifestation were presented.
