**3. Conclusion**

Autoantibodies are group of antibodies that are directed against self antigen. These antibodies recognized normal molecules in the cells as foreign and dangerous. As a result of that, large group of reactions take place in which these autoantibodies recognized normal molecules and generate various immunological response against them. In consequence, these autoantibodies also interact with other protein molecule in order to generate a series of reactions causing binding to the self molecules. Binding of autoantibodies to self molecules can be recognized by various immune cells that mainly responsible for the damage and excretion of these molecules. For examples, there are various types of autoantibodies and their associated antigens found in in SLE (**Table 1**). These self damaged molecules are called as auto-antigen and finally treat as foreign molecule and damage by various immune cells.


**Table 1.** Major types of autoantibodies and their associated antigens in SLE.
