**4. Conclusion**

RA is a complex disease that develops through a series of events often referred to as disease continuum. It is an autoimmune and inflammatory disease that can be further aggravated with the increased production and secretion of autoantibodies (RF ACPA, anti-cartilage type II antibodies) and the secretion of proinflammatory cytokines (TNF, IL-1, IL-6). With a better knowledge and understanding of the crosstalk between the molecules involved in RA disease pathogenesis, it would be easier to identify better markers for RA disease as well as design and administer specific and efficient therapeutics that can control RA pathogenesis and deliver long term and permanent remission of the disease.
