**Indicators of Preeclampsia in Correlation with Maternal Cytokines in Pregnancy Indicators of Preeclampsia in Correlation with Maternal Cytokines in Pregnancy**

DOI: 10.5772/intechopen.76344

Ana Daneva Markova, Marija Hadzi-Lega, Goran Dimitrov, Gligor Tofovski, Jadranka Georgievska, Elena Dzikova and Ivo Kjaev Ana Daneva Markova, Marija Hadzi-Lega, Goran Dimitrov, Gligor Tofovski, Jadranka Georgievska, Elena Dzikova and Ivo Kjaev

Additional information is available at the end of the chapter Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.76344

#### **Abstract**

Aim: the purpose of the actual study was to evaluate, in the third trimester of pregnancy, the relationship between the formation of anti-inflammatory IL-10 cytokine and several indicators of moderate and severe preeclampsia. Materials and methods: in the third trimester of gestation, examination of the biochemical markers of preeclampsia (PE) and maternal IL-10 levels was conducted in 100 women with pregnancies complicated by varying degrees of preeclampsia and in 100 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Patients with preeclampsia were categorized into moderate and severe preeclampsia groups according to the degree of preeclampsia. Logistic regression of the different parameters for the occurrence of severe preeclampsia analysis was used to determine the predictive value. Results: the regression analysis detected systolic blood pressure of 160 mmHg or higher, diastolic blood pressure of 100 mmHg or higher, persistent proteinuria in pregnancy, serum LDH concentration of 450 U/L or higher, and reduced serum concentrations of IL-10 as significant predictors of severe preeclampsia. Conclusion: significantly, lower IL-10 concentrations in maternal serum in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe form of preeclampsia.

**Keywords:** cytokines, indicators, preeclampsia, biochemical markers, prediction
