**Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs** Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for

DOI: 10.5772/intechopen.72007

Leila Figueiredo de Miranda, Kátia Lucia Gonçalves Cunha, Isabella Tereza Ferro Barbosa, Terezinha Jocelen Masson and Antonio Hortêncio Munhoz Junior Leila Figueiredo de Miranda, Kátia Lucia Gonçalves Cunha, Isabella Tereza Ferro Barbosa, Terezinha Jocelen Masson and

Application in Drugs

Additional information is available at the end of the chapter Antonio Hortêncio Munhoz Junior

http://dx.doi.org/10.5772/intechopen.72007 Additional information is available at the end of the chapter

#### Abstract

People with skin lesions caused by burns, ulcerations and other complications, independent of degree and extension of the problem, has induced the search for methods and materials to optimize the process of tissue repair in matter of time and quality. Thus, materials made by synthetic polymers have been used and improved due to overwhelming demand. The efficacy of dressings and bandage depends on a variety of factors such as biocompatibility, composition uniformity, low cost, long validity, flexibility, and so on. In this chapter, hydrophilic membranes based on polyvinylpyrrolidone-PVP/poly(vinyl alcohol)-PVAl and chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electronbeam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physicochemical tests. Pseudoboehmite nanoparticles were obtained from aluminum nitrate by a sol–gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, thermal analysis, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling, greater attraction and greater resistance to elongation at break in tension, although significantly lower fraction of gel membranes contains only agar and PVP. It was verified that the presence of chitosan nanoparticles and pseudoboehmite promotes a decrease in the formation of cross-links during irradiation of hydrophilic membranes.

Keywords: PVP, PVAl, chitosan, pseudoboehmite, nanotechnology, hydrophilic membranes

© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and eproduction in any medium, provided the original work is properly cited.
