**4. Conclusion**

The patients who undergo plastic surgery procedure can experience various types of pain, including background pain, breakthrough pain, and procedural pain. Treatment for each type of plastic surgery and resulted pain requires a specific approach and must be individualized to the patient. There are three main techniques in acute pain management postoperatively, such as systemic analgesia, regional analgesia, and local/topical analgesia. Currently, pain management through intravenous injection or continuous central neuraxial and peripheral nerve block is more controllable and safer since the invention of pain pump, which commonly use the principal of patient-controlled analgesia. Multimodal treatment seems to have significant benefits, postoperative dosing becomes more complex, and adverse drug interactions and drug overdose become more likely. There is some combination that has demonstrated a good effect in multimodal analgesia. PCA intravenous, patient-controlled epidural analgesia (PCEA) and patient-controlled regional analgesia (PCRA) can be combined with other pain killers, such as paracetamol, NSAIDs, alpha-2-delta modulators (gabapentin and pregabalin), N-methyl-D-aspartate (NMDA) antagonists (ketamine and magnesium), alpha-2-agonists (clonidine and dexmedetomidine), TAP block, continuous wound infusion system using pain pump, and tumescent analgesia with local anesthetic.
