**Meet the editor**

Helena Lenasi is an assistant professor of Physiology employed at the Institute of Physiology, Faculty of Medicine, University of Ljubljana, Slovenia. She obtained her MD title in 1996 and her PhD in 2003, both at the University of Ljubljana. Her working activities mainly include teaching and education. She gives lectures in Physiology for pre- and postgraduate students at the

Faculty of Medicine and Faculty of Sport at the University of Ljubljana. Her main research interests are cardiovascular and exercise physiology with a focus on human microcirculation in health and disease. She is a member of the Slovenian Physiological Society as part of the Federation of European Physiological Societies, the Medical Chamber of Slovenia, and the European Society for Microcirculation. She is an editor of the *Slovenian Medical Journal* and *Southeastern European Medical Journal* and has served as a reviewer and author of scientific papers and textbook chapters.

Contents

**Preface IX**

Chapter 1 **Endothelium at a Glance 1** Helena Lenasi

Claudio Aguayo

**Dysfunction 49**

**Arterial Aging 75**

**Preeclampsia 113**

Gennady T. Sukhikh

Escudero

Rafael Ramírez-Chamond

Yumeng Guo and Yu Wang

Chapter 2 **Hox Genes in Adult Tissues and Their Role in Endothelial Cell**

Chapter 3 **Endothelial Cell Senescence in the Pathogenesis of Endothelial**

Chapter 5 **Sensing Fluid-Shear Stress in the Endothelial System with a Special Emphasis on the Primary Cilium 89**

Chapter 6 **Endothelial Dysfunction as a Consequence of Endothelial Glycocalyx Damage: A Role in the Pathogenesis of**

Meriem Rezgaoui, Andres Rodriguez, Kurt Herlitz and Carlos

Marina M. Ziganshina, Ekaterina L. Yarotskaya, Nicolai V. Bovin and

Estefanía Nova-Lampeti, Valeria Aguilera, Katherine Oporto, Paula Guzmán, Valeska Ormazábal, Felipe Zúñiga, Carlos Escudero and

Julia Carracedo, Rafael Ramírez-Carracedo, Matilde Alique and

**Differentiation and Angiogenesis 29**

Chapter 4 **Targeting Endothelial SIRT1 for the Prevention of**
