5. Effects of moderate caloric restriction on obese patients—personal observations

In the next section, we would like to present the data of our studies where we investigated the effect of moderate CR on: (i) endothelial cell function especially involved in angiogenesis, (ii) production of adipokines, angiogenic and angiostatic factor and (iii) oxidative stress. Based on our previous studies that have already been published [78] and the data from the literature, we hypothesized that moderate CR, because it is not so burdensome and reflect a real-life situation, seems to be optimal to achieve an improvement of EC.
