**Acknowledgements**

This study was supported by the *Plan Estatal de Investigación Científica y Técnica y de Innovación 2013–2016* and the *Instituto de Salud Carlos III* (grant number PI14/01140), co-financed by European Regional Development Fund. *Axudas para a consolidación e estructuración de*  *unidades de investigación competitivas*, *Xunta de Galicia* (grant number ED431B 2016/022). The work of Beatriz Paradela-Dobarro was supported by *Instituto de Salud Carlos III* (grant number FI11/00325).

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