**Meet the editor**

Prof. Ntambwe Malangu, born in Kabinda, Congo (DRC), is a pharmacoepidemiologist with public health expertise in drug safety issues. He is currently the Head of the Department of Epidemiology and Biostatistics at the School of Public Health at Sefako Makgatho Health Sciences University, Pretoria, South Africa; a Production Editor for *PULA: Botswana Journal for African Studies*; as

well as a reviewer for a handful of international peer-reviewed journals. He has worked in both private and public sectors of the healthcare industry in several African countries. Since 2006, he has been working as an international health consultant and technical advisor with major development partners. In this capacity, he has contributed to several health system strengthening initiatives across the Anglophone, Lusophone, and Francophone African countries. He is a well-known trainer in supply chain management of health commodities and pharmaceuticals as well as in pharmacy and public health practice themes. Malangu holds a Bachelor's degree in Pharmacy from the University of Kinshasa (1991), a Master of Medical Science degree (Pharmacology and Toxicology) from the Medical University of Southern Africa (2003), a PhD degree (Pharmacoepidemiology and Pharmacovigilance) (2007), and a Doctor of Medical Sciences degree (Injury Epidemiology and Toxicovigilance) from the University of Limpopo (2012). Malangu has over 60 publications including scientific abstracts and letters, books, book chapters, and full papers.

Contents

**Preface VII**

**Adverse Effects of Drugs 1**

Kai On Chu and Calvin C.P. Pang

**to Depressive Symptoms 37** Yuki Murakami and Yukio Imamura

Chapter 4 **Application of Pharmacokinetics in Early Drug**

Alejandra Cano Paniagua and Pedro Amariles

Ntambwe Malangu

**Development 57**

Chapter 5 **Hepatotoxicity by Drugs 77**

Chapter 6 **Side Effects of Glucocorticoids 93**

**Adverse Effects 125**

Liliana Mititelu-Tartau

Irmak Sayın Alan and Bahadır Alan

Chapter 7 **New Antidepressant Medication: Benefits Versus**

Chapter 1 **Introductory Chapter: Linkages between Pharmacokinetics and**

Chapter 2 **Pharmacokinetics and Disposition of Green Tea Catechins 17**

Chapter 3 **A Critical Risk Factor for a Major Side Effect of Interferon-Alpha**

**Therapy: Activated Indoleamine 2,3-Dioxygenase 1 is Related**

Katherine Dunnington, Natacha Benrimoh, Christine Brandquist, Nadia Cardillo-Marricco, Mike Di Spirito and Julie Grenier

Maria Bogdan, Eliza Gofita, Daniela Cornelia Calina, Adina Turcu-Stiolica, Anca Oana Docea, Tudor Adrian Balseanu, Adrian Camen, Gratiela Eliza Popa, Gabriela Rusu, Ina Cristofor, Liliana Pavel and
