**[11C]Carbon Dioxide: Starting Point for Labeling PET Radiopharmaceuticals Radiopharmaceuticals**

**[<sup>11</sup>C]Carbon Dioxide: Starting Point for Labeling PET** 

DOI: 10.5772/intechopen.72313

Lingyun Yang, Peter J. H. Scott and Xia Shao Additional information is available at the end of the chapter

Lingyun Yang, Peter J. H. Scott and Xia Shao

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.72313

#### **Abstract**

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Positron emission tomography (PET) is a powerful *in vivo* imaging technique capable of providing dynamic information on biochemical processes in the living human subject. Applications of PET in oncology, neurology, psychiatry, cardiology and other medical specialties continue to grow. The use of PET relies on the characteristics and availability of appropriately labeled radiopharmaceuticals. Carbon-11 is one of the most useful radionuclides for PET chemistry, since its introduction into a biologically active molecule dose not modify the biochemical properties of the compound. [11C]Carbon dioxide ( 11CO2 ), produced by cyclotron, is the most common and versatile primary labeling precursor in the production of 11C–labeled radiopharmaceuticals.

**Keywords:** positron emission tomography, Carbon-11, radiopharmaceutical, molecular imaging, cyclotron
