**Very Low-Calorie Diets in Type 2 Diabetes Mellitus: Effects on Inflammation, Clinical and Metabolic Parameters Effects on Inflammation, Clinical and Metabolic Parameters**

**Very Low-Calorie Diets in Type 2 Diabetes Mellitus:** 

DOI: 10.5772/intechopen.72167

Luis M. Román-Pintos, Geannyne Villegas-Rivera, Ernesto G. Cardona-Muñoz, Adolfo D. Rodríguez-Carrizalez, Aldo Moreno-Ulloa, Nicole Rubin and Alejandra G. Miranda-Díaz Adolfo D. Rodríguez-Carrizalez, Aldo Moreno-Ulloa, Nicole Rubin and Alejandra G. Miranda-Díaz Additional information is available at the end of the chapter

Luis M. Román-Pintos, Geannyne Villegas-Rivera,

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.72167

Ernesto G. Cardona-Muñoz,

#### **Abstract**

Type 2 diabetes mellitus (DM) is a chronic and multifactorial disease strongly linked to a low-grade inflammatory process. Thus far, type 2 DM is generally regarded as an incurable disease by common therapies. However, very low-calorie diet (VLCD) regimens have demonstrated beneficial and rapid effects on glucose metabolism in subjects with type 2 DM. These beneficial effects include improvement of diabetes complications, insulin sensitivity and reduction in glycaemia, glycated hemoglobin (HbA1C), and triglyceride levels. VLCD regimens commonly comprise no more than 800 kcal/day and are therefore associated with rapid weight loss in overweight and obese individuals. This group of diets positively affects local/systemic inflammation and oxidative stress (OS) by modulating inflammatory cytokines, adipokines and endogenous antioxidant levels. The investigation of VLCDs in the field of type 2 DM treatment is progressively augmenting due to the multiple benefits in cardiometabolic health of overweight/obese subjects with type 2 DM. Here, we gather and review the evidence regarding the role of inflammation and OS in individuals with type 2 DM under VLCD regimens.

**Keywords:** very low-calorie diet, obesity, type 2 diabetes mellitus remission, oxidative stress, adipokines

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