**Meet the editor**

Prof. Neeraj Kumar Agrawal, DM (Endocrinology), is Professor and the Head of the Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. He has clinical and research training in endocrinology and metabolism. He completed his DM course in 2000 and since then is actively involved in teaching and training

in the subspeciality. He has keen interest in reproductive endocrinology and adolescent endocrinology, diabetes and thyroid disorders. He has published over 80 scientific publications in peer-reviewed journals and conference proceedings. He has edited a book on "Thyroid Hormone". He is an examiner to training centres of endocrinology. He is actively involved in the Endocrine Society of India and is a speaker in annual conferences.

Kiran Singh, PhD, is an Assistant Professor in the Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India. She completed her PhD degree in the year 2005 from Cytogenetic Laboratory, Banaras Hindu University, Varanasi, India. She specializes in reproductive genetics including diabetes and diabetic foot ulcer genetics, genetics of male and

female infertility, PCOS, endometriosis and recurrent miscarriage. She has over 65 scientific publications in peer-reviewed national and international journals with good citations. She is a principal or key investigator on over eight active grants. She has also published a book on male infertility under Springer publication and many book chapters. She has many recognitions and awards to her credit. She is an editorial member and academic editor of many reputed journals. She has also delivered invited lectures in national and international conferences.

Contents

**Preface VII**

Chapter 1 **Introductory Chapter: Polycystic Ovarian Disease: The Rainbow**

Abha Kiran, Uma Pandey and Neeraj Kumar Agarwal

Işık Kaban, Filiz Cebeci, Melek Aslan Kayıran and Vefa Asli Erdemir

Cringu Antoniu Ionescu, Ina Popescu, Mihail Banacu and Mihai

Chapter 5 **Incretin System: New Pharmacological Target in Obese Women**

Mojca Jensterle Sever, Simona Ferjan and Andrej Janez

**Without Color (SPECTRUM) 3**

Chapter 2 **Controversies in Polycystic Ovary Syndrome 9**

Chapter 3 **Lean Women with Polycystic Ovary Syndrome 23**

Chapter 4 **Lifestyle Changes and Weight Loss: Effects in PCOS 39**

**with Polycystic Ovary Syndrome 57**

Chapter 6 **Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option? 79** Vaduneme K. Oriji and Kennedy Nyengidiki

**Section 3 Therapy for Polycystic Ovarian Disease 37**

**Section 2 Controversies in Pathophysiology 7**

Elham Pourmatroud

Dimitriu

**Section 1 Introduction 1**
