**2. Safer pesticides**

Safer pesticides are those chemicals which have no or minimum acute or chronic toxicity to mammals and harmless to non-target organisms as well as non-persistent in the environment. The harmful effects of pesticides to non-target organisms can be overcome to certain extend by increasing the selectivity pf pesticide. Pesticide selectivity as such can be attained by either physical or biochemical means that is often combined in practice. In the former, only the target species is exposed to the control agent, and this can be accomplished by special formulation or precise application techniques [4]. In the later, selectivity is based on differences of the biochemical processes or target receptors of the pest and non-pest species. Furthermore, physiochemical factor such as differential uptake by and translocation within target and nontarget organisms can contribute to disparate biological activities [5]. Nevertheless, differences in metabolic pathways, which convert toxic xenobiotics into less harmful and readily excretable product, and in metabolic rates of various organisms are frequently the basis of selectivity.
