**Meet the editor**

Miroslav Blumenberg, PhD, was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his PhD at MIT in organic chemistry; this he followed up with two postdoctoral study periods at Stanford University. Since 1983 he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is a co-director of a training grant in

cutaneous biology. Dr. Blumenberg's research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on skin. He has published over 100 peer-reviewed research articles and graduated numerous PhD and post-doctoral students. Dr. Blumenberg lives in New York, USA, with his wife and two children.

Contents

**Preface VII**

**Resistance 3**

**Progression 45**

Zuzana Kostecká

Urda

**Section 1 Melanoma: Pathways and Mechanisms 1**

Chapter 2 **LncRNAs as Biomarkers for Melanoma 25**

Chapter 1 **Epigenetics in Melanoma Development and Drug**

Heinz Hammerlindl and Helmut Schaider

Chapter 3 **The Multiple Roles of Tyrosinase-Related Protein-2/L-**

Adina L. Milac and Gabriela Negroiu

Chapter 4 **The Modern Approach to Targeting Melanoma 87** Jane O'Sullivan and Donal O'Connor

**Section 2 Melanoma: Targets and Treatments 85**

**and Future Directions 109**

**Dopachrome Tautomerase in Melanoma: Biomarker, Therapeutic Target, and Molecular Driver in Tumor**

Chapter 5 **Possibilities for the Therapy of Melanoma: Current Knowledge**

Marcela Valko-Rokytovská, Jana Šimková, Mária Milkovičová and

Yixuan James Zheng, Ricardo Moreno Traspas and Susana Ortiz-
