**3. Physiological implication of VDAC affection by membrane bound proteins**

It has been shown that the disruption of mitochondrial functions is linked to the occurrence of mutations in genes encoding various types of intermediate filament proteins. In humans, the different morphology, distribution, and function of mitochondria in patients with neurological disorder [20, 21], types of myopathies [22, 23], or epidermolysis bullosa simplex [24] were documented. The cytoskeleton proteins as tubulin, desmin, vimentin, and plectin have been found to interact with mitochondrial outer membrane, where they are involved in the ATP/ADP transmission control through VDAC, thus mediating or influencing mitochondrial functions.
