**2. Cancer: a modern epidemic**

Cancer has a very high mortality and morbidity rate worldwide [1, 2] and is scaling up every year. In 2012 14 million people were diagnosed with cancer and 8.2 million people died due to cancer and cancer-associated diseases [3]. It is estimated that these figures will double by the year 2030 [4]. Patients are treated with radiotherapy, chemotherapy, and combination therapy. However, radiotherapy has been reported to be toxic and chemotherapy has been suggested to partially reduce the number of side effects. So, a chemotherapeutic agent is preferred to cure cancer [2]. Chemotherapy considerably enhances the survival rate of cancer patients. But, it is recognized to lead to side effect such as cardiovascular disease after growing survival population of a cancer patient with chemotherapy [5]. Therefore, cardiovascular diseases induced by chemotherapy are associated with high morbidity and mortality. The issue of heart damage caused by chemotherapy is a top priority due to the elevated cancer population treated with chemotherapy [6]. Anthracycline antibiotic groups are one of chemotherapeutic agents that is widely used in the treatment of solid and hematological cancer [7]. It has been indicated that the 5-year survival rate of childhood cancer patients was 30% before the discovery of group agents. However, this rate is around 80% today [8]. Still, extensive studies report that the group causes cardiotoxicity [6].
