**Author details**

catalase upregulation) possibly explaining the alleged statin antioxidant properties. Together, the experimental evidence presented in this review suggests that statins' detrimental effects could be prevented by antioxidants administration such as CoQ10, L-carnitine, and creatine.

We are grateful to the financial support of Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP # 2011/50400-0 and # 2014/11261-2), Obesity and Co-morbidities Research Center (OCRC/Fapesp # 2013/07607-8), Conselho Nacional de Desenvolvimento Científico e Tecnológico

(CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

FCCP Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

**Acknowledgements**

398 Mitochondrial Diseases

**Abbreviations**

**Conflict of interest statement**

The authors declare no conflicts of interest.

ALT Alanine transaminase AST Aspartate transaminase

CK Creatine kinase

CoQ10 Coenzyme Q10

Cys A Cyclosporin A

ER Endoplasmic reticulum

FPP Farnesyl-pyrophosphate

GPP Geranyl-pyrophosphate

GSSG Glutathione oxidized

GSH Glutathione

FH Familial hypercholesterolemia

GGPP Geranylgeranyl-pyrophosphate

IMM Inner mitochondria membrane

HMG-CoA 3-Hydroxy-3-methylglutaryl coenzyme-A

Estela N.B. Busanello<sup>1</sup> , Ana C. Marques<sup>1</sup> , Estela Lorza-Gil<sup>2</sup> , Helena C.F. de Oliveira<sup>2</sup> and Anibal E. Vercesi<sup>1</sup> \*

\*Address all correspondence to: anibal@unicamp.br

1 Faculty of Medical Sciences, Department of Clinical Pathology, UNICAMP, SP, Brazil

2 Institute of Biology, Department of Structural and Functional Biology, UNICAMP, SP, Brazil
