**10. Conclusion**

As it follows from this review, the proper course of metabolic processes in the mitochondria requires direction of transport systems to the needs of the organism. The activities of transporters can be regulated differently by hormones, phosphorylation and dephosphorylation, cytokines, concentration of metabolites, and individual nutrition components, which can alter their amount and activity. Most metabolites or their precursors can be mutually transported by different transport systems to provide the desired concentrations on both sides of the mitochondrial membranes. The specificity of transport and regulation of compounds in different organs and tissues provide various isoforms encoded by different nuclear genes. More detailed knowledge of transport mechanisms can contribute to better diagnosis and treatment of metabolic disorders.
