**1. Introduction**

Obesity is a major health problem and an increased risk factor that worsens cardiovascular events leading to higher morbidity and mortality. [1] Several cardiovascular diseases can also occur due to structural and functional changes of the myocardium through excess fat deposition and other mechanisms related to obesity [2]. However, the mechanisms of relation between obesity and cardiovascular events are unclear. Nevertheless, pharmacological therapy for obesity has great potential to improve cardiovascular problems. Several anorexcigenic peptides

© 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

have been studied as potential drugs in the treatment of obesity [3]. Recent evidence showed that some brain regions may not only be involved in food intake regulation but also play an important role in the regulation of cardiovascular blood homeostasis [4]. The rising prevalence of both obesity and heart failure make this association an important target for prevention. Therefore, it is important to determine the common mechanisms regulating both obesity and cardiovascular events. Identification of signaling pathways linking obesity and cardiovascular disease is importantforthedevelopmentofnoveltherapeutics.Here,we summarize the current informationonthe role of anorexigenicpeptideprokineticininobesity andcardiovascularrenal diseases, emphasizing prokineticin receptor‐1 signaling in these events.
