**11. Conclusions**

This chapter may bring a significant contribution to the updating of knowledge of the genetic susceptibility and provide a better clarification of which variants are truly associated with the predisposition to develop an obese phenotype. This chapter may also help to understand better the genetic diversity that could be associated in subjects with genetic forms of obesity. However, this chapter may help to understand this complex problem and the different approaches to treatment. In these forms of genetic obesity, the team approach to therapy (nurse educators, nutritionists, exercise physiologists, and counsellors) is the basis for treatment. Dramatic reductions in BMI are difficult to achieve and sustain, so counselling and therapy should start with realistic goals that emphasize gradual reductions of body fat and BMI and maintenance of weight loss. Finally, this chapter may provide news on the need for new therapeutic approaches in the field of childhood obesity as the basis of the hyperphagia treatment, a typical feature of these syndromes.
