**Meet the editors**

Dr. Omer Devaja graduated from the Medical School of Novi Sad, Serbia. He was awarded a PhD for his research in the field of molecular biology of ovarian and endometrial carcinoma at Guy's and St Thomas' Hospital, London, and ICRF, UK. In 2000 he completed his subspeciality training in gynaecologic oncology at Guy's and St Thomas' Hospital. In the 2003 he was

awarded a scholarship to attend advanced gynaecologic oncology laparoscopic training in the University of Québec, Canada, and the National Cancer Institute, Cairo, Egypt. He is currently working as a gynaecologic oncology surgeon at the Kent Oncology Centre, Maidstone, UK. He has written on a wide range of topics in the field of gynaecologic oncology and edited the atlas on laparoscopic surgery in gynaecology. He is director of subspeciality training in gynaecological oncology and visiting professor at the Medical School, University of Novi Sad, Serbia. His research interests include sentinel node detection and minimal access surgery in gynaecologic oncology.

Dr. Andreas Papadopoulos trained at King's College School of Medicine, University of London. He completed his general training in gynaecology and gynaecologic oncology at Guy's and St Thomas' Hospital, London. His research MD was in the field of immunobiology of ovarian cancer. He was awarded an RCOG scholarship to attend both the MD Anderson Cancer Center, Hou-

ston, Texas, USA, and the Tata Memorial Hospital, Mumbai, India. He has been a lead cancer clinician as well as a gynaecologic oncology cancer lead at the Kent Oncology Centre, UK. He is currently a gynaecologic oncology surgeon and MDT lead at the Kent Oncology Centre. He has written a wide range of articles in gynaecologic oncology, including ovarian cancer. His research interests include immunobiology of ovarian cancer, sentinel node detection, and minimal access surgery in gynaecologic oncology.

Contents

**Preface VII**

**Section 1 Pathogenesis and Molecular Biology of Ovarian Cancer 1**

Chapter 1 **Ovarian Cancer Genetics: Subtypes and Risk Factors 3** Jeff Hirst, Jennifer Crow and Andrew Godwin

Chapter 2 **Signaling Pathways Related to Nerve Growth Factor and miRNAs in Epithelial Ovarian Cancer 39**

Chapter 3 **Ovarian Cancer Overview: Molecular Biology and Its Potential**

Ghassan M. Saed, Robert T. Morris and Nicole M. Fletcher

Chapter 4 **New Insights into the Pathogenesis of Ovarian Cancer:**

Chapter 5 **Genomic Copy Number Alterations in Serous**

Joe R. Delaney and Dwayne G. Stupack

Chapter 6 **Ubiquitin Signaling in Ovarian Cancer: From Potential to**

Chapter 7 **The Role of Circulating Biomarkers in the Early Diagnosis of**

Vega and Carmen Romero

**Clinical Application 57**

**Oxidative Stress 83**

**Ovarian Cancer 111**

**Challenges 135** Sumegha Mitra

**Section 2 Diagnosis and Screening 155**

**Ovarian Cancer 157**

Ece Gumusoglu and Tuba Gunel

Carolina Vera, Rocío Retamales-Ortega, Maritza Garrido, Margarita

Joana Assis, Deolinda Pereira, Augusto Nogueira and Rui Medeiros
