**Meet the editor**

William S. Wilke received his Bachelor of Science degree from the University of Notre Dame and Doctor of Medicine degree from the Medical College of Wisconsin in 1971. He completed medical internship and residency at the Akron City Hospital. He completed rheumatology training and remained at the Cleveland Clinic Foundation (CCF) for 37 years, retiring in April 2011. He was

working as a consultant/strategic advisor at the Crescendo Bioscience from 2012 to 2015. During his career at CCF, he was a chairman of the Medical Grand Rounds Committee and the Pharmacy and Therapeutics Committee, and the Head of Subspecialty Clinics from 1981 to 1995. From 1990 to 2011 (till retirement), he was an associate editor of the *Cleveland Clinic Journal of Medicine*. His outside activities included "Meet the Professor" as an expert in rheumatoid arthritis at the American College of Rheumatology Annual Meetings, 1991–1993, and he participated as a member of the United States Pharmacopeia General Committee, 1995–2000. Currently, he is the author of 132 various publications. He was the editor of the *Methotrexate Therapy in Rheumatic Disease*, Marcel Dekker Inc., 1989, and *New Insights into Fibromyalgia*, InTech, 2011. He was the author of *The Cleveland Clinic Guide to Fibromyalgia*, Kaplan Publishing, 2010.

Contents

**Preface VII**

**Fibromyalgia 1** William S. Wilke

Rodríguez-Lara

Quintans Júnior

William S. Wilke

Chapter 1 **Introductory Chapter: A Challenge to the Concept that**

**and Autophagy in Fibromyalgia 13**

Chapter 3 **Nonpharmacologic Treatment for Fibromyalgia 35** Fatmanur Aybala Koçak and Emine Eda Kurt

**Inflammation Plays a Prominent Pathogenic Role in**

Chapter 2 **The Role of Oxidants/Antioxidants, Mitochondrial Dysfunction,**

Chapter 4 **Natural Products as Promising Pharmacological Tools for the**

Chapter 5 **Recognize Comorbid Fibromyalgia Syndrome in Order to Better**

**Evaluate Selected Rheumatic Diseases 79**

Alejandra Guillermina Miranda-Díaz and Simón Quetzalcóatl

**Management of Fibromyalgia Symptoms – A Review 57** Renan Guedes Brito, Priscila Laise Santos, Marlange Almeida Oliveira, Lícia Tairiny Santos Pina, Angelo Roberto Antoniolli, Jackson Roberto Guedes da Silva Almeida, Laurent Picot, Gokhan Zengin, Jullyana Souza Siqueira Quintans and Lucindo José
