**Meet the editors**

Dr. Boutou received her B.Sc. from the Faculty of Biology, National & Kapodistrian University of Athens and her Ph.D. from the Dept. of Biochemistry & Molecular Biology of the same Faculty (recipient of a national fellowship). Her post-doctoral research, in Athens and Luebeck Universities, mainly focused on DNA repair mechanisms. She is currently member of the Molecular

Genetics Lab of Laiko General University Hospital, Athens, Greece, where her research interests focus on liquid biopsies and epigenetics of globin gene expression regulation. She is author of many scientific publications in peer-reviewed journals, book chapters and poster communications.

Prof. Dr. Horst-Werner Stuerzbecher is currently working in molecular cancer pathology as a professor at the Institute of Pathology, University Clinic of Schleswig-Holstein Campus Luebeck in Germany. After his studies in biology at the Westfaelische-Wilhelms University Muenster, Germany, he obtained his PhD (Dr. rer. biol. hum.) degree from the Department

of Biochemistry at the University of Ulm, Germany. Between 1986 and 1991, Prof. Stuerzbecher continued his research activities at the Marie-Curie Research Institute in Oxted, Surrey, UK, focusing on the tumor suppressor p53. He habilitated in genetics at the Institute of Genetics of the Johannes-Gutenberg University in Mainz, Germany, in 1992 and was appointed as a senior scientist at the Department of Tumor Virology of the Heinrich-Pette Institute in Hamburg, Germany. Prof. Stuerzbecher received a Heisenberg stipend from Deutsche Forschungsgemeinschaft (DFG) to lead his own research group at the Heinrich-Pette Institute focusing on the contribution of DNA repair processes to carcinogenesis, especially the interaction of the tumor suppressor protein p53 and the human RAD51 recombination protein. In 1996, he accepted a position as professor of Genetics at the Institute of Human Genetics of the University Clinic of Schleswig-Holstein Campus Luebeck, Germany.

In addition to his work as a reviewer for various international journals and research grants, Prof. Stuerzbecher was also a coordinator of national and international research projects, for example, an international research project within the 5th Framework European Union.

Contents

**Preface VII**

Chapter 1 **Ubiquitylation and SUMOylation: An Orchestrated Regulation**

Chapter 2 **The Five Families of DNA Repair Proteins and their Functionally**

Sara Espinoza-Corona, Ma Luisa Bazán-Tejeda, Ulises Omar García-

Jun Lu, Zhi-Feng Xi, Xiao-Ying Huang, Qiang Xia and Xi-Dai Long

**Complex/Cyclosome in the Regulation of DNA Double Strand**

Chapter 5 **The Roles of Cullin RING Ligases and the Anaphase Promoting**

Chapter 6 **The Cross Talk among Autophagy, Ubiquitination, and DNA**

Chapter 7 **Interlace between Chromatin Structure, DNA Repair and**

Francesca Nazio, Emiliano Maiani and Francesco Cecconi

Attya Bhatti, Shanzay Ahmed, Arooma Jannat and Peter John

**During DNA Damage Repair 1**

Lepe and Rosa Ma Bermúdez-Cruz

Niko Moses and Xiaohong Mary Zhang

Chapter 3 **Regulation of the Base Excision Repair Pathway by**

Rachel Jane Carter and Jason Luke Parsons

Chapter 4 **The Role of Deubiquitinases in DNA Double-Strand**

Debjani Pal and Matthew K. Summers

**Repair: An Overview 103**

**Ubiquitination 123**

**Relevant Ubiquitination 19**

**Ubiquitination 37**

**Break Repair 57**

**Break Repair 75**
