**7. Conclusion**

The newly produced GMOs could be very harmful for the environment, microbial life, and human and animal health, but they are not always harmful. The producers of genetically modified organisms should analyze the global transcriptional profiles of the GMO in comparison with the safe commercial variety to assess the presence or absence of unintended modifications. This data would also provide comprehensive and unbiased information about the metabolic pathways altered in the new organism that can be helpful in designing the strategy for biosafety risk assessment of GMOs.

Transcriptome analysis is very useful for detection and evaluation of transgenics produced by RNAi technology or transcription factor transformations. However, evaluation of gene expression is a very sensitive phenomenon and variable in different tissues and changing conditions. So, for transcriptional analysis, the selection of suitable sample and experimental conditions is critical for reliable results.
