*8.2.2. Activity spectrum*

Both cefepime and amikacin individually have become a victim of high level of resistance [52]. This is where precisely, Potentox is used in combating these multidrug-resistant pathogens as Potentox has demonstrated in vitro and in vivo activity against these resistant isolates to which cefepime and amikacin are resistant individually. Global surveillance studies demonstrate that the actual acquired fluoroquinolone resistance rates are highly variable and are as high as almost 100%, particularly in Asia, whereas resistance rates in Europe and North America range from <10% in rural areas to >30% which is still pretty high. This highlights the importance of Potentox use to target multiple drug resistance effectively which developed both in community and in hospital settings.

Multi-centric randomized comparative open-labeled phase 3 trial of synergistic antibiotic combination of cefepime and amikacin versus cefepime alone was conducted in nosocomial pneumonia and showed superiority of Potentox in efficacy over cefepime alone.

Potentox and Elores can serve as a true carbapenem sparer as medically important Gramnegative bacteria are developing resistance very fast against this valuable class of antibiotic. In the era of antimicrobial resistance, the judicious use of different antimicrobials in a balanced fashion can help us in preserving these antibiotics for longer duration.
