**Acknowledgements**

This chapter was supported by Portuguese funds, through the national Foundation for Science and Technology – FCT to cE3c (UID/BIA/00329/2013). Thanks are also due, for the financial support to CESAM (UID/AMB/50017/2013), to FCT/MEC through national funds, and the cofunding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020. A postdoctoral grant to OMCCA (SFRH/BPD/102965/2014) supported by FCT is also acknowledged.
