**6. Animal genetic models developed for incontinence/SUI studies**

During last decade, investigators have developed and tested animal models of SUI in the female rat, seeking to mimic the symptoms of SUI in female patients. Bilateral pudendal nerve crush injury or transection or sciatic nerve transection has been used to cause SUI in rats. The VD model was used by Lin et al. [28] to simulate the damage that occurs in the pelvic floor during vaginal delivery of children. They demonstrated the feasibility of creating a mouse model of acute SUI by VD. Distention volumes of 0.1–0.3 ml in 20 g female mice of strain C57BL/6 resulted in significant reductions of LP, possibly due to partial urethral denervation. This novel model of SUI in mice could be used in future mechanistic studies of female SUI treatment. The childbirth induced vaginal distension, and SUI can be correlated but women recover out of these transient changes with only few remaining symptomatic for SUI. There is a need to develop specific mouse genetic models for incontinence/SUI induced by VD. Further studies can be performed to know the spontaneous cure of incontinence.
