**14. Responsibilities of the investigators after approvals**

#### • Sign the final copy of protocol

*The main investigator should sign and hereby accept the responsibility of trial.*

#### • Submit the requested document

*The main investigator should provide the requested form including budget, Gantt chart, and consent forms to the sponsor, the research institute and ethics committee.*

#### • Registering the protocol of the trial in one of the clinical trial registries

*Now most high-quality journals necessitate researchers to submit their work in one of clinical trial registries before patient's enrollment into the trial and provide its code at the time of submission to the journal. He/she must also agree with publication policy of journal and publisher.*

#### • Work according to the protocol and good clinical practice guidelines

*The investigator must ensure that he/she acts in accordance with the sponsor-approved protocol and globally accepted standard of GCP.*

#### • Collaborate with monitor

*The investigator should collaborate in on-site inspections and in corresponding.*
