**Clinical Trials in Pregnant Women with Preeclampsia**

**Clinical Trials in Pregnant Women with Preeclampsia**

DOI: 10.5772/intechopen.70185

Leonel García Benavides, Diego Hernández Molina, Jessica L. Barajas Vega, Sylvia E. Totsuka Sutto, Fernando Grover Paéz, Francisco J. Hernández Mora, Ernesto J. Ramírez Lizardo, Sara Pascoe Gonzalez, David Cardona Müller and Ernesto G. Cardona Muñoz Molina, Jessica L. Barajas Vega, Sylvia E. Totsuka Sutto, Fernando Grover Paéz, Francisco J. Hernández Mora, Ernesto J. Ramírez Lizardo, Sara Pascoe Gonzalez, David Cardona Müller and Ernesto G. Cardona Muñoz Additional information is available at the end of the chapter

Additional information is available at the end of the chapter

Leonel García Benavides, Diego Hernández

http://dx.doi.org/10.5772/intechopen.70185

#### **Abstract**

Preeclampsia (PE) is the leading cause of preterm birth by medical indication when associated with premature detachment of placenta normoinserta, and Intrauterine growth restriction (IUGR) is associated with high perinatal morbidity and mortality and longterm sequelae. The main problem of PE is threefold: the diagnostic difficulty, the complicated interrelationship of the pathophysiological processes, and the vulnerability of the maternal-fetal binomial to the therapeutic interventions. The approach for management with PE is preventing its late occurrence in pregnancy. The key to preventing PE is knowledge of the factors that trigger the pathophysiological processes that culminate in the presentation of PE. Understanding the developmental characteristics of the placenta in pregnancy at high risk for PE is essential for understanding the pathophysiology and developing strategies for prevention. When deciding that the population of study is a group of pregnant women, the first ethical criteria that need to be reviewed are those aimed at the protection of the fetus. There are no specific guidelines on how to assess fetal well-being during pregnancy routinely in the clinic, and this deficiency is shifted to clinical research with pregnant women.

**Keywords:** preeclampsia, eclampsia, pregnancy induced-hypertension, complications in pregnancy women

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© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons
