**Meet the editor**

Dr. David Gaze studied biochemistry at undergraduate and master's level in West Yorkshire followed by a PhD degree in Clinical Biochemistry in London, United Kingdom. He is currently a lecturer in Clinical Biochemistry at the University of Westminster and honorary cardiac research scientist within the Department of Chemical Pathology, Clinical Blood Sciences at St George's Hospi-

tal and Medical School, London.

He has authored and co-authored in excess of 150 peer-reviewed papers and 200 abstracts, as well as presented at over 50 internationally invited conferences. He has contributed five book chapters to cardiovascular-related textbooks as well, and is writing a textbook on cardiac troponin. He is a peer reviewer for 25 medical journals. He is the commissioning editor for review articles for the *Annals of Clinical Biochemistry and Laboratory Medicine* and is the co-editor-in-chief of *Practical Laboratory Medicine*.

His academic research interests are in the development and clinical utility of cardiac biomarkers for the detection of cardiovascular disease with a special interest in the cardiorenal population.

He is a member of the Royal Society of Medicine of London and the Association for Clinical Biochemistry, of which he chairs the Clinical Sciences Review Committee for the Annals of Clinical Biochemistry. He is also a member of the American Association of Clinical Chemistry, Institute of Biomedical Sciences, Institute of Biology, European Society of Pathology, and the Pathological Society of Great Britain and Ireland and an associate member of the Royal Institution of London.

Gaze and colleagues have won a number of awards including two distinguished Abstract awards from the National Academy of Clinical Biochemistry as well as Diploma for Oral Presentation regarding D-dimer, natriuretic peptide and cardiac troponin in dialysis patients presented at the 17th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine and the 60th National congress of the Netherlands Society of Clinical Chemistry and Laboratory Medicine in Amsterdam in 2007.

Contents

**Preface VII**

**Section 1 Neuropathophysiology 1**

**Condition 23**

Elangovan Muthu Kumaran

**Section 2 Endocrine Pathophysiology 49**

**Microbiota 69**

Hideo Orimo

**and Dyskinetic Rodent Models 35** Jesús Pérez-Ortega and José Bargas

Chapter 1 **Body Dysmorphic Disorder: Characteristics, Psychopathology, Clinical Associations, and Influencing Factors 3**

Chapter 2 **Alteration in Nasal Cycle Rhythm as an Index of the Diseased**

Chapter 3 **Changes in the Striatal Network Connectivity in Parkinsonian**

Chapter 4 **Transthyretin in the Evaluation of Health and Disease in**

Chapter 5 **The Intricate Relationship between Diabetes, Diet and the Gut**

Chapter 6 **Hypophosphatasia: A Systemic Skeletal Disorder Caused by**

**Alkaline Phosphatase Deficiency 101**

Gratiela G. Pircalabioru, Ariana Picu, Laura Petcu, Marcela Popa and

**Human and Veterinary Medicine 51**

Csilla Tóthová and Oskar Nagy

Mariana Carmen Chifiriuc

**Section 3 Structural Pathophysiology 99**

Silva Novaes and Helder Miguel Fernandes

Patricia Tatiana Soler, Cristina Michiko Harada Ferreira, Jefferson da
