3. Conclusion

The investigations of the antibacterial screening, carried out for these new classes of compounds, reveal the fact that they present activity, especially toward the gram-positive bacteria, in comparison with the standard streptomycin. The increased antibacterial activity of the metal complexes can be accounted for by a cluster of reasons that refer to the chelation theory, nature of the ligand and of the metal ion, the geometry of the metal complexes, liposolubility, the presence of the co-ligands, and a series of sterical and pharmacokinetic factors. We can say that, ten of the complexes synthetized can be successfully used instead of streptomycin, where there is resistance to this antibiotic.

### Author details

Elena Mihaela Pahontu

Address all correspondence to: elenaandmihaela@yahoo.com

Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania

## References


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3. Conclusion

Author details

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