*6.2.8. PARP inhibitors*

These agents were demonstrated to prevent the cancer cell's single stranded break repair mechanism, leading to tumor cell death [149].

A phase II trial in metastatic/recurrent gastroesophageal cancer studied the effectiveness of administrating the PARP inhibitor olaparib as a second-line treatment [150], demonstrating improved OS. There is also an ongoing phase III study of second-line treatment using paclitaxel with or without olaparib in advanced gastric cancer patients [151].

Veliparib was developed to increase the effectiveness of DNA-damaging therapies, such as chemo- or radiotherapy. A study of the efficacy of veliparib associated with the FOLFIRI regimen in gastric cancer is pending results [152].
