*6.2.1.2. Tyrosine kinase inhibitors (TKIs) of HER2*

Lapatinib is an oral TKI of EGFR and HER2, which was studied in combination with standard chemotherapy in patients with HER2-positive advanced gastric adenocarcinomas in the phase III LOGIC study [45] and in the phase III Asian TyTAN trial without demonstrating an improvement in OS. Currently, the MAGIC-B study is evaluating the addition of lapatinib to perioperative epirubicin, cisplatin, and capecitabine (ECX) chemotherapy in patients with HER2 (+) gastric cancers [103].
