**2.6. Gastric apudoma type 3**

Type 3 gastric apudomas are known as sporadic gastric tumors, representing about 10–15% of all gastric apudomas, and develop independently hypergastrinemia as well as gastric endocrine cell hyperplasia (**Table 4**). More frequently they present as a single polypoid tumor usually greater than 2 cm in size [28]. These tumors are composed mainly by enterochromaffin-like cells, and differently from the other gastric apudoma, they have an aggressive clinical evolution. These tumors present histopathological signs corresponding to the clinical evolution of worse prognosis such as angioinvasion, rapid growth, mitotic activity, and high Ki-67 index.
