**3. Anti-antigenic**

Angiogenesis was postulated 40 years ago as an essential event for tumors to grow beyond a critical size of few millimeters. Except for physiological conditions requiring angiogenesis such as embryogenesis and wound healing, inhibiting neovascularization may contribute to tumor growth arrest with minimal toxicities to normal tissues. Therefore, targeting molecules involved in neovascularization has gained recognition as a rational therapeutic option.
