Preface

**Section 4 Molecular Biological Mechanism Involved in Patients with**

Chapter 8 **Systemic Inflammatory Reaction in Gastric Cancer: Biology and Practical Implications of Neutrophil to Lymphocyte Ratio, Glasgow Prognostic Score and Related Parameters 143** Ilze Strumfa, Tatjana Bogdanova, Arturs Kalva, Boriss Strumfs, Roberts Rumba, Andrejs Vanags, Inese Drike, Dzeina Mezale, Arnis Abolins, Arvids Jakovlevs, Dainis Balodis and Janis Gardovskis

Chapter 9 **Surgical Management of Malignant Gastric Tumours: A**

**Section 5 Treatment Strategies in Patients with Gastric Cancer 219**

**Importance of Dormant Cancer Stem Cells 243**

**Therapeutic Decisions in Patients with Gatric Cancer 265**

Chapter 10 **Molecular Targeting Therapy for Gastric Cancer: Current**

Chapter 11 **Gastric Cancer with Liver Metastasis (GCLM) and the**

**Section 6 Key-role of Pathologists in the Diagnosis and in the**

Chapter 12 **Malignant Gastric Tumours: The Role of Pathologist in the Diagnosis and for Therapeutic Decisions 267**

**Advances and Obstacles 221**

Vitězslav Marek and Štefan Durdik

Daniela Lazar, Sorina Taban, Marioara Cornianu, Alexandra Faur,

Roberts Rumba, Andrejs Vanags, Arturs Kalva, Tatjana Bogdanova, Inese Drike, Dzeina Mezale, Marta Vitola, Janis Gardovskis and Ilze

Chapter 7 **Molecular Prognostic Factors in Gastric Cancer 109**

Ioan Romosan and Adrian Goldis

**Gatric Cancer 107**

**VI** Contents

**Practical Guide 199**

Shouji Shimoyama

Alexander Quaas

Strumfa

Gastric cancer remains an important issue in the world of oncology. In 2013, it ranked fifth by global incidence and second by mortality. It is true that the death rates have decreased significantly in the USA and Europe over the last 100-year period; meanwhile, gastric cancer is characterized by poor prognosis and high mortality, except in early diagnosed cases.

The basic and clinical oncological research increased extremely in the last years, and our knowledge from this field is changing from day to day.

The same applies to the field of gastric cancer.

This book deals with details of the results of the most recently carried out basic and clinical observations (as the possible role of Epstein-Barr virus in tumor genesis, gastric carcinoma stem cells, molecular heterogeneity of gastric cancer, a summary of prognostic factors, treat‐ ment strategies, the actualities in targeting therapy, the key role of teamwork in the diagno‐ sis and therapeutic decisions, etc.).

The authors of 12 different book chapters, apart from the Introductory Chapter, are basic and clinical researchers from Chile, Spain, France, Slovenia, Romania, Japan, Slovakia, Lat‐ via, Germany, and Brazil, and they together give an excellent cross section of our updated basic and clinical research in the field of gastric cancer.

The conclusions of these abovementioned observations fall between the results of classical prospective, randomized, multiclinical, multinational (and meta-analyzed) generally accept‐ ed studies (in accordance with the presently applied and internationally accepted protocols) and the scientifically-based (however individual) molecular targeting organ therapies.

#### **Gyula Mózsik, MD, PhD, ScD (Med.)**

Professor Emeritus of Medicine First Department of Medicine University of Pécs, Hungary

#### **Oszkár Karádi, MD, PhD**

Associate Professor Institute of Oncotherapy, University of Pécs, Hungary

**Section 1**

**Introductory Chapter**

**Provisional chapter**
