**Transistors as an Emerging Platform for Portable Amplified Biodetection in Preventive Personalized Point‐of‐Care Testing**

Zhihui Yi and Jonathan Sayago

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/67794

#### **Abstract**

The impressive improvement in biomolecular detection has gone from simple chemical methods to sophisticated high throughput laboratory machines capable of accurately measuring the complex biological components and interactions. In the following chap‐ ter, we focus our attention on transistor‐based devices as an emerging platform for easy‐to‐use, portable amplified biodetection for preventive personalized medical appli‐ cations and point‐of‐care testing. Electronic sensing devices comprise biosensors based on field‐effect transistors (bio‐FETs) and organic electrochemical transistors (OECTs). Transistor sensing devices can transduce electronic and ionic signals thereby creat‐ ing an effective human‐machine communication channel. In this chapter, we survey the progress done on the development of transistor innovative concepts to examine biological processes, i.e., biosensors integrated with textiles, flexible substrates, and biocompatible materials. Electrochemical and field‐effect transistors can operate at low voltages possibly serving for highly sensitive, selective, and real‐time sensing devices. The exploration of biosensors integrates different disciplines such as organic electronics, biology, electrochemistry, and materials science.

**Keywords:** bio‐FETs, OECTs, transistor biosensors, electrolyte‐gated transistors
