**Toxicogenomics of Bisphenol A and Neurodevelopmental Disorders**

Bingling Wang, Ruqin Gao and Da‐Hong Wang

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.68415

#### **Abstract**

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10.1289/ehp.1002572

90 Bisphenol A Exposure and Health Risks

10.1681/ASN.2015030312

10.1159/000445203

ijpharm.2016.03.003

Bisphenol A (BPA) has been widely used in many industrial and consumer products and is known as an endocrine‐disrupting chemical. To find the underlying genetic basis and molecular mechanisms of BPA‐associated neurodevelopmental disorders (NDs), this chapter addressed the toxicogenomics of BPA with publicly accessed Comparative Toxicogenomics Database. The present results indicated that the key cellular components (CC) of the nervous system such as neuron, synapse, dendrite and axon are common in CC annotation; the commonly found molecular functions are neurotransmitter receptor or transducer binding or activity; and the main common biological processes include syn‐ aptic signalling, cognition, learning or memory, behaviour, the development of nervous system and brain. Neuroactive ligand‐receptor interaction, dopaminergic, glutamatergic and serotonergic synapses, monoamine transport and synaptic vesicle pathway were the common pathways. Simultaneously, the BPA‐disease may share the common pathways with drug addictions such as cocaine addiction. Unique pathways might also contribute to the BPA action in different NDs such as one carbon metabolism and detoxification of oxidative stress in Down syndrome. Although GO and pathway results indicate some common annotations, the predicted PPI molecular function clusters are quite different for each ND. In addition, some of the NDs share the same transcription factors (TFs) and miRNAs, which indicate these disorders have the similar expression profiles. Finally, chemicals having comparable interacting genes to BPA should be considered.

**Keywords:** bisphenol A, toxicogenomics, neurodevelopmental disorders

© 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
