**3. Microarray data and differently expressed gene screening**

To explore the possible clinical application of the genes curated, we used Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/) and ArrayExpress (http: //www. ebi.ac.uk / arrayexpress) to find the microarray data for peripheral blood, and special tissue gene expres‐ sion profiling in NDs. The differently expressed genes (DEGs) in each ND samples were iden‐ tified. If more than one microarray dataset is found, all the datasets are integrated to perform the meta‐analysis for the DEGs. Based on the inference scores and the counts of inference BPA‐interacted genes, we only selected ID, LD, Sch, ASD, AD and BD as our target diseases for the possible microarray data.

We only found some common genes for BD between CTD and the microarray data. It was in the GSE46449 [10] and only four common genes (BDNF, CACNA1C, CPLX2, HTR2A, SP4) were found. Therefore, the existing microarray data is not enough for further annotation.
