**Tandem-, Domino- and One-Pot Reactions Involving Wittig- and Horner-Wadsworth-Emmons Olefination Wittig- and Horner-Wadsworth-Emmons Olefination**

**Tandem-, Domino- and One-Pot Reactions Involving** 

DOI: 10.5772/intechopen.70364

Fatima Merza, Ahmed Taha and Thies Thiemann

Additional information is available at the end of the chapter Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.70364

Fatima Merza, Ahmed Taha and

## **Abstract**

Thies Thiemann

The Wittig olefination utilizing phosphoranes and the related Horner-Wadsworth-Emmons (HWE) reaction using phosphonates transform aldehydes and ketones into substituted alkenes. Because of the versatility of the reactions and the compatibility of many functional groups towards the transformations, both Wittig olefination and HWE reactions are a mainstay in the arsenal of organic synthesis. Here, an overview is given on Wittig- and Horner-Wadsworth-Emmons (HWE) reactions run in combination with other transformations in one-pot procedures. The focus lies on one-pot oxidation Wittig/HWE protocols, Wittig/HWE olefinations run in concert with metal catalyzed cross-coupling reactions, Domino Wittig/HWE—cycloaddition and Wittig-Michael transformations.

**Keywords:** Wittig olefination, one-pot reactions, Domino reactions, tandem reactions, Horner-Wadsworth-Emmons olefination
