**Author details**

Selim Öncel

for well-appearing infants with negative blood and CSF cultures and negative inflammatory findings in CSF may safely be discontinued 48–72 h after receiving negative CSF culture

**Weight < 1200 g Weight = 1200–2 000 g Weight = 1200–2000 g Weight > 2000 g Weight > 2000 g**

Antibiotic Age: 0–4 wk Age: 0–7 d Age > 7 d Age: 0–7 d Age > 7 d Ampicillin 50, every 12 h 50, every 12 h 50, every 8 h 50, every 8 h 50, every 6 h Gentamicin 2.5, every 18 h 2.5, every 12 h 2.5, every 8 h 2.5, every 12 h 2.5, every 8 h Cefotaxime 50, every 12 h 50, every 12 h 50, every 8 h 50, every 12 h 50, every 8 h Vancomycin 15, every 24 h 10, every 12 h 10, every 12 h 10, every 8 h 10, every 8 h

**Table 3.** Dosages (mg/kg) of some antibacterial drugs used for neonatal meningitis [15].

LP should be repeated after 24–48 h after the beginning of antimicrobials for CSF is expected to become sterile in 24–48 h with appropriate therapy. In some centers, successful therapy for HSV meningitis is confirmed with a negative polymerase chain reaction in CSF, obtained with

Early complications of neonatal meningitis are increased: intracranial pressure, ventriculitis, cerebritis, hydrocephalus, brain abscess, cerebral infarction, and subdural effusion or empyema [22]. Late complications include hearing loss, abnormal behaviors, developmental retardation, cerebral palsy, focal motor deficits, seizures, and hydrocephalus, some of which may develop due to neonatal sepsis or cerebritis in infants without meningitis. Neonates recovered from meningitis should be referred for brainstem evoked auditory response audiometry 6–8 weeks after completion of therapy and then followed regularly for visual, auditory, and cognitive

Case fatality rate is highest in meningitides due to Gram-negative organisms (17%), which are

Taking Turkey as an example, a PubMed search by the author using the Medical Subject Headings terms groups "infant meningitis Turkey," "newborn meningitis Turkey," "neonate meningitis Turkey," "infant meningitis Turkish," "newborn meningitis Turkish," and

succeeded by those caused by fungi (12%) and Gram-positive bacteria (6%) [10, 23].

results from the microbiology laboratory [10].

wk: week(s); d: day(s); h: hour(s).

92 Selected Topics in Neonatal Care

**10. Complications and follow-up**

functions.

**11. Prognosis**

**12. Conclusion**

a repeat LP at the end of a 21-day antiviral therapy.

Address all correspondence to: selimoncel@doctor.com

Division of Pediatric Infectious Diseases, Department of Pediatrics and Child Health, Section of Internal Medical Sciences, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
