**1. Introduction**

Primary percutaneous coronary intervention (PPCI) angioplasty saves life and improves out‐ comes in patients with acute ST‐segment elevation myocardial infarction (STEMI). The vascu‐ lar access in this life‐threatening situation has an impact on mortality and morbidity. In this chapter, we will discuss the preferred vascular access in PPCI; radial vs. femoral and review the studies that compared right radial vs. left radial in acute myocardial infarction.

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