**12. Prognosis and conclusion**

The Takotsubo syndrome is essentially a benign disease and the prognosis is favourable in most patients. The regional wall-motion abnormalities usually resolve spontaneously within a few days to weeks; however, there have been instances where TTS has persisted due to complications associated with apical thrombus formation [64, 65]. Recent studies have demonstrated that the in-hospital death rate ranges between 0 and 8%, while recurrence rates fluctuate anywhere between 0 and 15% [66, 67].

These results have eschewed renewed interest into the study of Takotsubo syndrome and mechanisms contributing to its pathophysiology. Patients are now recommended routine follow-ups after 3–6 months to evaluate the progress of disease and help better understand its evolutionary dynamics.

Limited current knowledge and often contradictory data have fuelled the debate surrounding the Takotsubo syndrome. There is an urgent need for multiple randomised controlled trials and large registries to optimise existing clinical goals and management strategies, and the launch of InterTAK registry is a step forward in this regard.
