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92 A Comprehensive Review of Urticaria and Angioedema

Emel Erdal Çalıkoğlu, Didem Mullaaziz and Asli Kaptanoğlu

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.68676

#### **Abstract**

Chronic urticaria (CU), one of the most frequent skin disorders, is defined as the repeated occurrence of red, swollen, itchy and sometimes painful hives (wheals), and/or angioedema (swellings in the deeper layers of the skin), for more than 6 weeks [1, 2]. CU has an estimated worldwide prevalence of approximately 1% [3], which includes spontaneous and inducible types. In chronic spontaneous urticaria (CSU), the most common type of CU, symptoms occur without a specific trigger [1, 3]. In contrast, in chronic inducible urticaria (CIndU), symptoms occur in response to specific stimuli, such as exposure to cold, heat or pressure [4]. Patients may suffer from CSU and CIndU in parallel [2]. Chronic urticaria (CU) is defined as the repeated occurrence of red, swol‐ len, itchy and sometimes painful wheals, and/or angioedema, for more than 6 weeks. CU includes spontaneous and inducible types. In chronic spontaneous urticaria (CSU), the most common type of CU, symptoms occur without a specific trigger. Treatment of urticaria and/or angioedema mainly consist of antihistamines, short courses of corti‐ costeroids, other immunosuppressive, and anti‐inflammatory agents. Angioedema is a deeper expression of urticaria which is classified by allergic, hereditary, acquired, and angiotensin‐converting enzyme inhibitor (ACEI)‐induced forms.

**Keywords:** urticaria, treatment, management, angioedema
