**2. Creating a schematic model**

of HHV1 & 2 with neurogranin could have an interaction with viral transport into the host cell

Secretogranin-3 UniProtKB-Q8WXD2 (SCG3\_HUMAN) is a protein of molecular mass 53,005 Da. Secretogranin-3 (AA position: 139–190) has a similarity to the polyprotein of Japanese encephalitis virus (UniProtKB-G3LHD8 (G3LHD8\_9FLAV) (sequence ID: SBO07578.1 AA position: 2744 to (**Figure 22**). Secretogranin-3 is a member of the chromogranin/secretogranin

**Figure 21.** BLAST output of envelope glycoprotein of human alpha herpes virus 2 showing similarity to human protein

**Figure 22.** BLAST output of polyprotein of JE 2 showing similarity to human protein secretogranin-3.

Golgi network and subsequently to the host nucleus [38].

*1.2.13. JE 2 peptide similarity to human protein secretogranin-3*

neurogranin.

294 Antibody Engineering

The sequence similarities in agrin,caprin-2,2′,3′-cyclic-nucleotide 3′-phosphodiesterase, galanin peptide, kinesin-like protein, neurofilament heavy polypeptide, neurogranin and secretogranin-3 with its corresponding pathogenic peptide/s could have a number of cellular-level implications which include alternations in receptor binding, signaling/synaptic transmission, metabolic alteration, inflammation, resulting in autoimmunity and consequently neuropathy (**Figure 23**) [11, 40].

**Figure 23.** A model for the modes of host-pathogen interaction and possible intracellular regulation of metabolic activities.
