**4. Therapy of allergic airway disease in childhood**

Although there are numerous studies, management of allergic disease is still a matter of a debate. According to the data management of allergic diseases, consider avoidance of the risk factors, treatment, and induction of tolerance. In that light the management of allergic diseases depends on how easy is to avoid the triggers, whether there are multiple triggers and how easy is to induce tolerance. The possibility to avoid certain allergen mainly depends on the nature of that allergen. For ubiquitous allergens such as house dust mites or pollens it is usually impossible to avoid, unlike for animal dander [34]. There are also some studies suggest that food allergen avoidance in pregnancy, lactation, and infancy have preventive role in the development of food allergy, and possibly other allergic diseases. The only current recommendations to prevent allergic disease are exclusive breastfeeding at least 4–6 months and if breastfeeding is insufficient or not possible, hypoallergenic formula for the high-risk infants [35–37]. The most common approach used in allergic diseases treatment is symptomatic therapy in step management strategies. Pharmacologic therapy is tailored to the primary symptom or symptoms and to the severity of symptoms without modifies the long-term outcome of allergy. The optimal utilization of pharmacologic therapies varies among regions and countries and varying preference of therapies in different populations [38, 39]. According to the clinical data, more targeted therapies include monoclonal antibodies against IgE and against various proallergic cytokines (e.g., anti-IL-5, anti-IL-13, and anti-IgE). Although expensive, these therapies are useful in the management of selected patients who are usually unresponsiveness to standard pharmacological treatment [40].
