**7. Conclusion**

Summarizing, using *Agrobacterium*‐mediated genetic transformation with the strain carrying the genetic construct for silencing of γ‐kafirin gene, we have obtained transgenic sorghum plants with significantly improved *in vitro* protein digestibility. The basis of such improved digestibility may be a reduction in the level of γ‐kafirin, which causes formation of poorly digestible kafirin oligomers and development of vitreous endosperm. Further studies of these plants, including analysis of the expression of the genetic construct at the molecular level, will contribute to the understanding of regularities of endosperm development and possible use of these plants in sorghum breeding.

Obstacles along this path have both scientific reasons (instability of transgene expression, effects of transgenes on agronomically important traits) and social basis (public opposition to genetically modified plants). In future, to overcome public fears on "danger" of genetically modified organisms, sorghum plants with a modified synthesis of kafirins should be obtained by using marker‐free technologies of genetic engineering or technologies of genome edit‐ ing. With obtaining objective data from biosafety experiments, genetically modified sorghum plants with improved kafirin digestibility will be in demand on the market because they will combine favorable traits of sorghum (high grain productivity, resistance to drought stress) with a high nutritive value.
