**8. Natural history**

Unfortunately, we have very little data on the clinical course of this condition. Cohen *et al*. was the only one who studied this sphere through a survey he sent to 29 patients with lymphocytic esophagitis. In his cohort, patients report an improvement in their symptoms with medical treatment (proton pump inhibitor or anti-TNF for Crohn's cases). Control endoscopies were performed in 22 out of 29 patients and 9 esophageal biopsies showed persistence of lymphocytic esophagitis despite treatment [3].

Current available literature points out that lymphocytic esophagitis is a chronic condition [12]. The risk of esophageal neoplasia is still unknown.
