**On Treatment Outcomes in Coeliac Disease Diagnosed in Adulthood**

Claes Hallert1 and Susanne Roos2

*1Coeliac Centre at Norrkoping Hospital, Norrköping, 2 Linköping University, ISV, Campus Norrkoping Sweden* 

#### **1. Introduction**

178 Celiac Disease – From Pathophysiology to Advanced Therapies

Ljungman G, Myrdal U. 1993. Compliance in teenagers with coeliac disease–a Swedish

Malamut G, Afchain P, Verkarre V et al. 2009. Presentation and long-term followup of

Meloni A, Mandas C, Jores RD et al. 2009. Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal. *J Pediatr,* 155(1):51-5 NIH-National Institute of Health Consensus Development Conference Statement on Celiac

Pietzak MM. 2005. Follow-up of patients with celiac disease: achieving compliance with

Rashid M, Cranney A, Zarkadas M et al. 2005. Celiac disease: Evaluation of the diagnosis and dietary compliance in Canadian children. *Pediatrics*, 116:e754-e759. Romaldini CC, Barbieri D, Okay TS, et al. 2002. Serum soluble interleukin-2 receptor,

Rubio-Tapia A, Kelly DG, Lahr BD et al. 2009. Clinical staging and survival in refractory celiac disease: a single center experience. *Gastroenterology*, 136(1):99-107. Sategna Guidetti C, Solerio E, Scaglione N, et al. 2001. Duration of gluten exposure in adult

Silvester J, Rashid M 2010. Long-term management of patients with celiac disease: Current practices of gastroenterologists in Canada. *Can J Gastroenterol*, 24;(8):499-509. Silvester J, Rashid M. 2007. Long-term follow-up of individuals with celiac disease: An evaluation of current practice guidelines. *Can J Gastroenterol*, 21(9):557-64. Tursi A, Brandimarte G, Giorgetti GM. 2003. Lack of usefulness of anti-transglutaminase

Tursi A, Brandimarte G, Giorgetti GM et al. 2006. Endoscopic and histological findings in

Ventura A, Magazzu G, Greco L. 1999. Duration of exposure to gluten and risk for

Wahab PJ, Meijer JW, Mulder CJ. 2002. Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery. *Am J Clin Pathol*, 118:459-63. Walker-Smith JA, Guandalini S, Schmitz J et al. 1990. Revised criteria for diagnosis of coeliac

Zarkadas M, Cranney A, Case S et al. 2006. The impact of a gluten-free diet on adults with coeliac disease: Results of a national survey*. J Hum Nutr Diet*, 19:41-49.

Autoimmune Disorders in Celiac Disease. *Gastroenterology*,117:297-303. Viljamaa M, Kaukinen K, Huhtala H, et al. 2005. Coeliac disease, autoimmune diseases and

interleukin-6, and tumor necrosis factor-alpha levels in children with celiac disease:

coeliac disease does not correlate with the risk for autoimmune disorders. *Gut*,

antibodies in assessing histologic recovery after gluten-free diet in celiac disease. *J* 

the duodenum of adults with celiac disease before and after changing to a gluten-

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disease. Report of Working Group of European Society of Paediatric

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free diet: a 2-year prospective study. *Endoscopy*, 38:702-7.

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136(1):81-90.

49:502-5.

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Coeliac disease (CD) is generally regarded as an intestinal disorder that can be fully treated by a gluten free diet (GFD). Indeed, this remains perfectly true in most medical aspects as regards the recovery of the small intestinal mucosa appearance, the blood count as well and the mineral bone density. In fact, life expectancy is similar to that of general population.

From a wider perspective, however, taking the subjective outcome of treatment into account the health-related quality of life (Hallert & Lohiniemi, 1999) and well-being i.e. patientbased perspectives refer to the perceived health state such as social, emotional, physical well-being or functioning, incorporating both positive and negative aspects of life. In Gastrointestinal (GI) disease the most relevant aspect of well-being pertains to relief of abdominal pain.

For adults struggling with a GFD for years to remain in clinical remission CD is not just associated with troublesome bowel complaints such as Indigestion, Diarrhoea, Constipation and Abdominal pain (Midhagen & Hallert, 2003). CD is also connected with a wide range of persistent symptoms outside the GI tract typically experienced by women diagnosed in adulthood that include various bodily pain syndromes and frank mood disorders (Ludvigsson et al., 2007), all making them apt to seek more health care services than women of same age in general population (Roos et al., 2011). Of interest considering the concept of CD in remission, a study compared health care costs per patient over 2 consecutive yrs of 137 women with CD treated median 7 yrs with 411 age-matched female population in Southeast Sweden using data derived from a local administrative database covering all health care services including prescribed drugs, imaging and lab. The results showed that the 93 per cent of the women CD used health-care services the 2-yr period amounting to mean Eur 5675 as compared with Eur 5414 for controls (p<0.05), the difference mainly accounted for by excessive use of hospital care (Eur 5864 *vs* Eur 5215) and prescription of drugs (Eur 993 *vs* Eur 702) (Hallert et al , 2011).

All of this is consistent with the idea that reduction in well-being is a feature of longstanding CD at least in women living in Sweden but not in men for largely unclear reasons (Roos et al., 2006).

On Treatment Outcomes in Coeliac Disease Diagnosed in Adulthood 181

Fig. 1. Graph comparing dimensions of well-being in CD (solid line) and Crohns' disease

For being a basically benign disorder these characteristics are an intriguing and unexpected feature of CD (Fera et al.(2003) that may be easily overlooked by gastroenterologists in charge. A tentative explanation for the poor treatment outcome of especially women living with CD diagnosed in adulthood may reside in the problematic transition into a life as a coeliac in association with poor insights into the nature of CD, sometimes, referred to as an allergy necessitating constant control of every dish that is often dated from the time of the diagnosis and rarely entertained since by the health care system, Yet current wisdom considers the once assumed fears of ingesting traces of gluten to be no longer valid (Collin et al., 2004). Gaining proper disease knowledge would thus be reassuring to most women and particularly when put into a structured education programme like a Coeliac School as

Anxiety Depression Positive W-B Self-control General

Health

Vitality

The Coeliac School an educational concept is based on the problem based learning pedagogy and includes weekly meetings in groups of 7-9 conducted by a tutor acting as a moderator. Each educational session is set to cover a predetermined topic presented as a scenario. The topics are decided by the group members according to specific needs and desires, thought promote active rather than passive learning. The group members were encouraged to perform self-studies between the meetings to find answers on raised issues. At the next meeting the group members were expected to evaluate and reflect upon the gathered information and to what extent it impacts on their daily life. Developing issues were treated by a new brainstorming allowing the group to invite an outside expert as needed. The benefits from taking part in the Coeliac School include improvement in mood

A GFD is no single diet, nor simply foods devoid of gluten. Indeed, studies across Europe show that the composition of a GFD vary considerably between people and differ in several aspects from intakes as reported by general populations using food diaries. A study of adults in Sweden who had been on a GFD for 10 years revealed they had the same energy intake as general population controls of same age but lower daily intakes of fibres, niacin,

and reduction in GI complaints as well opportunities to update diet knowledge.

(dotted line) (Stjernman, 2011).

PGWB value

outlined (Ring Jacobsson L et al., 2011).

**5. The Coeliac School™** 

#### **2. Bowel symptoms** *vs* **well-being**

A study addressing whether the high rate of GI symptoms would explain the poor wellbeing of women living on a GFD confirmed close negative correlations between the GI symptoms and psychological well-being as assessed by the Gastrointestinal Symptom rating Scale (GSRS) total score and the Psychological General Well-being (PGWB) index, respectively. However, looking at directions of relationships the study showed that women with a high rate of GI symptoms showed no lower well-being than men with high rate GI symptoms. Furthermore, women with reduced well-being had not higher rates of GI symptoms than men with reduced well-being. Awaiting further studies it was concluded that any causal interrelations of bowel symptoms and subjective poor health remain unproven (Roos et al., 2009).

#### **3. Well-being and coping**

The poorer treatment outcome of women with CD may to some extent reflect the way they cope with the disorder and what factors they believe adversely impact on the subjective well-being.

To this connection studies indicate that women living with CD understand well-being and quality of life quite differently than men with CD. Men living with CD for years tend to focus on bodily sensations like physical endurance and bowel symptoms and they are prone to use a problem-oriented coping strategy approach.

Women treated for CD, on the other hand, are seeking an emotionally oriented strategy and emphasise the social consequences of being a coeliac and refer to the value of food, role identification, social functioning and feeling restricted by constant fatigue. Women are generally more frustrated men by the various bothering bowel symptoms that continue to despite adhering closely to the GFD.

#### **4. Everyday life with CD**

It may rather be that the numerous dilemmas and restrictions in everyday life facing especially women living with CD account for much of their perceived disease burden, comprising concerns about having to abstain from important things in life and the possibility that the children may develop CD in addition to the unmet expectations of the treatment. (Hallert et al, 2003), amounting to a sense of frustration and disappointment beyond the early happy phase of remission. As rightly pointed out (Ciacci, 2010) being diagnosed with CD implies accepting to have got a chronic illness and in addition to this a tricky dietary treatment that must last for life. Most people are capable to handle the ensuing psychic reactions pretty uneventful, whereas some develop signs of depression suggestive of a coeliac profile comprising two principal characteristics, namely, reactiveness with anger and/or frustration and Pessimism including a cluster of symptoms signalling, powerlessness and constant fatigue.

In addition, women are inclined to express worries about having CD that affects all areas of life past, present and future when they do something that is outside the daily routines to such extent that the well-being of adults with CD in remission is in the same range as in adults with quiescent Crohn's disease.

A study addressing whether the high rate of GI symptoms would explain the poor wellbeing of women living on a GFD confirmed close negative correlations between the GI symptoms and psychological well-being as assessed by the Gastrointestinal Symptom rating Scale (GSRS) total score and the Psychological General Well-being (PGWB) index, respectively. However, looking at directions of relationships the study showed that women with a high rate of GI symptoms showed no lower well-being than men with high rate GI symptoms. Furthermore, women with reduced well-being had not higher rates of GI symptoms than men with reduced well-being. Awaiting further studies it was concluded that any causal interrelations of bowel symptoms and subjective poor health remain

The poorer treatment outcome of women with CD may to some extent reflect the way they cope with the disorder and what factors they believe adversely impact on the subjective

To this connection studies indicate that women living with CD understand well-being and quality of life quite differently than men with CD. Men living with CD for years tend to focus on bodily sensations like physical endurance and bowel symptoms and they are prone

Women treated for CD, on the other hand, are seeking an emotionally oriented strategy and emphasise the social consequences of being a coeliac and refer to the value of food, role identification, social functioning and feeling restricted by constant fatigue. Women are generally more frustrated men by the various bothering bowel symptoms that continue to

It may rather be that the numerous dilemmas and restrictions in everyday life facing especially women living with CD account for much of their perceived disease burden, comprising concerns about having to abstain from important things in life and the possibility that the children may develop CD in addition to the unmet expectations of the treatment. (Hallert et al, 2003), amounting to a sense of frustration and disappointment beyond the early happy phase of remission. As rightly pointed out (Ciacci, 2010) being diagnosed with CD implies accepting to have got a chronic illness and in addition to this a tricky dietary treatment that must last for life. Most people are capable to handle the ensuing psychic reactions pretty uneventful, whereas some develop signs of depression suggestive of a coeliac profile comprising two principal characteristics, namely, reactiveness with anger and/or frustration and Pessimism including a cluster of symptoms signalling,

In addition, women are inclined to express worries about having CD that affects all areas of life past, present and future when they do something that is outside the daily routines to such extent that the well-being of adults with CD in remission is in the same range as in

**2. Bowel symptoms** *vs* **well-being** 

unproven (Roos et al., 2009).

**3. Well-being and coping** 

despite adhering closely to the GFD.

powerlessness and constant fatigue.

adults with quiescent Crohn's disease.

**4. Everyday life with CD** 

to use a problem-oriented coping strategy approach.

well-being.

Fig. 1. Graph comparing dimensions of well-being in CD (solid line) and Crohns' disease (dotted line) (Stjernman, 2011).

For being a basically benign disorder these characteristics are an intriguing and unexpected feature of CD (Fera et al.(2003) that may be easily overlooked by gastroenterologists in charge. A tentative explanation for the poor treatment outcome of especially women living with CD diagnosed in adulthood may reside in the problematic transition into a life as a coeliac in association with poor insights into the nature of CD, sometimes, referred to as an allergy necessitating constant control of every dish that is often dated from the time of the diagnosis and rarely entertained since by the health care system, Yet current wisdom considers the once assumed fears of ingesting traces of gluten to be no longer valid (Collin et al., 2004). Gaining proper disease knowledge would thus be reassuring to most women and particularly when put into a structured education programme like a Coeliac School as outlined (Ring Jacobsson L et al., 2011).

#### **5. The Coeliac School™**

The Coeliac School an educational concept is based on the problem based learning pedagogy and includes weekly meetings in groups of 7-9 conducted by a tutor acting as a moderator. Each educational session is set to cover a predetermined topic presented as a scenario. The topics are decided by the group members according to specific needs and desires, thought promote active rather than passive learning. The group members were encouraged to perform self-studies between the meetings to find answers on raised issues. At the next meeting the group members were expected to evaluate and reflect upon the gathered information and to what extent it impacts on their daily life. Developing issues were treated by a new brainstorming allowing the group to invite an outside expert as needed. The benefits from taking part in the Coeliac School include improvement in mood and reduction in GI complaints as well opportunities to update diet knowledge.

A GFD is no single diet, nor simply foods devoid of gluten. Indeed, studies across Europe show that the composition of a GFD vary considerably between people and differ in several aspects from intakes as reported by general populations using food diaries. A study of adults in Sweden who had been on a GFD for 10 years revealed they had the same energy intake as general population controls of same age but lower daily intakes of fibres, niacin,

On Treatment Outcomes in Coeliac Disease Diagnosed in Adulthood 183

This is in good keeping with an observation (Dorn et al., 2010) that psychosocial factors more strongly affect well-being and bowel symptoms in CD than the appearance of the gut mucosa, underscoring the limitations of a biomedical model to help understanding adults living with CD in proven remission. This would allow for applying biopsychosocial approach in assessing health in CD since there is no underlying mucosal damage to treat. Instead CD sufferers may require attention to their psychosocial distress and worries that

CD is a benign yet sometimes a troublesome disorder of the GI tract often surrounded by obsolete patient's beliefs dated from the time of the diagnosis, making the condition especially hard to successfully cope with. This is apparently true for many women who are frustrated find the outcome of the long-term treatment and self-management worse than expected at start. The complexity of living with CD and remain well extends far beyond keeping the mucosa free from signs of inflammation. Given the increasing prevalence of CD across the globe improving the long-term health of these people represents a major

Ciacci, C. (2010). Depression and anxiety in celiac disease, pp. 227- 231, In: *Real life with* 

Fera, T. Cascio, B. & Angelini, G. (2003). Affective disorders and quality of life in adult

Grehn, S. Fridell, K. & Lilliecreutz, M. (2001). Dietary habits of Swedish adult coeliac

Hallert C, Roos S, & Ring Jacobsson L. (2010). Coping and adapting to celiac disease, pp.

Hallert, C. & Roos, S. Grip, B. (2011). Swedish coeliac women in remission show raised health-care costs: Controlled study. *Proceedings of the UEGW, Stockholm, Sweden*. Hallert, C. Grännö, C. & Hultén S. (2001). Living with coeliac disease – controlled study of

Hallert, C. Sandlund, O. & Broqvist, M. (2003). Perceptions of health-related quality of life of

Hallert, C. Svensson, M. & Tholstrup, J. (2009) B vitamins improve health in patients with

men and women living with c oeliac disease for 10 years. *Scand J Car Sci* Vol 17,

coeliac disease living on a gluten- free diet. *Aliment Pharmacol Ther* Vol 29, pp. 811-

the burden of illness. *Scand J Gastroenterol* Vol 37, pp. 39-42.

Gastroenterological Association Publisher 2010 ISBN 978-1-60356-008-5 Collin, P. Thorell, L. & Kaukinen, K. (2004). The safe threshold for gluten contamination in

gluten-free products. *Aliment Pharmcol Ther* Vol 19, pp.1277-1283.

*Celiac disease Troubleshooting and Thriving Gluten Free*; The American

coeliac disease patients on a gluten-free diet. *Eur J Gastroenterol Hepatol* vol 15,

patients treated by a gluten-free diet for 10 years. *Scand J Nutrition* Vol 45, pp.178-

223-26. In: *Real life with Celiac disease Troubleshooting and Thriving Gluten Free;* The American Gastroenterological Association Publisher 2010 ISBN 978-1-60356-008-5. Hallert, C. & Lohiniemi, S. (1999). Quality of life of celiac patients living on a gluten-free

may include psychological support and treatment for the IBS-like symptoms.

**7. Conclusions** 

**8. References** 

challenge for any health care provider.

pp.1287–92.

pp.301-7.

16.

diet. (Ed.) *Nutrition* Vol 15, pp.795-97.

82.

folic acid, vitamin B-12, calcium, phosphorus and zinc. Moreover, clear discrepancies were observed between the groups in selecting foods among 28 food groups under study, particularly true for women (Grehn et al., 2001). A similar study conducted in UK showed generally adequate macronutrient intakes, while women tended have low daily intakes of fibre, magnesium, iron, zinc, manganese, selenium and folic acid but no differing energy intakes, suggesting they are prone to have sugary snack foods. (Wild et al, 2010).

There are good reasons to believe that a GFD is nutritionally unbalanced more often than routinely recognised in clinical practice, at risk to cause nutritional deficiencies that may be clinically important. Indeed, the low intakes of B vitamins in CD populations account for raised levels of plasma homocysteine, a marker of functional B vitamin deficiency. Lack of B vitamins may very well explain part of the depressive features of CD, gaining support by the results of a randomised controlled clinical trial adding 0.5 mg of vitamin B-12, 3 mg of vitamin B-6 and 0.8 mg of folic acid to the daily diet for six months that showed general improvement in well-being of adults on a GFD for many years, notably within Anxiety and Depression unlike for controls receiving placebo (Hallert et al., 2009). Accordingly, advising people to avoid of gluten should not be the sole focus of a GFD knowing eating oats, represents a major advance in CD therapy not only in adults (Högberg et al., 2004).

Indeed, oats is rich in dietary fibres and taking oats is generally found to raise the palatability of a GFD also largely appreciated for being cheap. Unfortunately. Oats is widely looked upon as cattle food that is at best just prejudice.

Over the past decade gluten intolerant sufferers have witnessed a vast increase in the availability of suitable foods in most Western countries only hampered by unfounded ideas that wheat starch or trace amounts of gluten can be harmful to the coeliac mucosa and thereby entertaining social phobia and restrictions in daily life. With an expanding food market on the internet novel gluten free products will be steadily entering the global arena. Rendering cereals like barley non toxic is however less likely to be seen in the near future.

#### **6. Managing CD beyond remission**

The ever growing prevalence of CD approaching 3 per cent (Myleus at al., 2009) represents an increasing challenge to any health provider to ensure that CD is successfully coped with by supporting CD sufferers to master every day life dilemmas through proper selfmanagement i.e learning to take control rather being controlled by food absorbing the entire life (Sverker et al., 2005)

To date, nursing appears to be a neglected component of the follow-up of adults with CD. In fact it may add values to the care of adults with CD, knowing that in some countries only 60 per cent of patients have a high level of confidence in the information provided from a dietician or gastroenterologist. Even more so, 1,000 adult members of the German Celiac Society identified dissatisfaction with the doctor–patient communication as one of the strongest predictors of poor well-being (Häuser et al., 2007)

In our experience CD sufferers diagnosed in adulthood only rarely need monitoring of the diet adherence. Follow-up routines should rather focus on life adjustments, medical procedures to symptom control and measures to uncover depression signs preferably managed by a dedicated multi-disciplinary team as employed in the care of adults with other chronic disorders.

This is in good keeping with an observation (Dorn et al., 2010) that psychosocial factors more strongly affect well-being and bowel symptoms in CD than the appearance of the gut mucosa, underscoring the limitations of a biomedical model to help understanding adults living with CD in proven remission. This would allow for applying biopsychosocial approach in assessing health in CD since there is no underlying mucosal damage to treat. Instead CD sufferers may require attention to their psychosocial distress and worries that may include psychological support and treatment for the IBS-like symptoms.

#### **7. Conclusions**

182 Celiac Disease – From Pathophysiology to Advanced Therapies

folic acid, vitamin B-12, calcium, phosphorus and zinc. Moreover, clear discrepancies were observed between the groups in selecting foods among 28 food groups under study, particularly true for women (Grehn et al., 2001). A similar study conducted in UK showed generally adequate macronutrient intakes, while women tended have low daily intakes of fibre, magnesium, iron, zinc, manganese, selenium and folic acid but no differing energy

There are good reasons to believe that a GFD is nutritionally unbalanced more often than routinely recognised in clinical practice, at risk to cause nutritional deficiencies that may be clinically important. Indeed, the low intakes of B vitamins in CD populations account for raised levels of plasma homocysteine, a marker of functional B vitamin deficiency. Lack of B vitamins may very well explain part of the depressive features of CD, gaining support by the results of a randomised controlled clinical trial adding 0.5 mg of vitamin B-12, 3 mg of vitamin B-6 and 0.8 mg of folic acid to the daily diet for six months that showed general improvement in well-being of adults on a GFD for many years, notably within Anxiety and Depression unlike for controls receiving placebo (Hallert et al., 2009). Accordingly, advising people to avoid of gluten should not be the sole focus of a GFD knowing eating oats,

intakes, suggesting they are prone to have sugary snack foods. (Wild et al, 2010).

represents a major advance in CD therapy not only in adults (Högberg et al., 2004).

looked upon as cattle food that is at best just prejudice.

strongest predictors of poor well-being (Häuser et al., 2007)

**6. Managing CD beyond remission** 

life (Sverker et al., 2005)

Indeed, oats is rich in dietary fibres and taking oats is generally found to raise the palatability of a GFD also largely appreciated for being cheap. Unfortunately. Oats is widely

Over the past decade gluten intolerant sufferers have witnessed a vast increase in the availability of suitable foods in most Western countries only hampered by unfounded ideas that wheat starch or trace amounts of gluten can be harmful to the coeliac mucosa and thereby entertaining social phobia and restrictions in daily life. With an expanding food market on the internet novel gluten free products will be steadily entering the global arena. Rendering cereals like barley non toxic is however less likely to be seen in the near future.

The ever growing prevalence of CD approaching 3 per cent (Myleus at al., 2009) represents an increasing challenge to any health provider to ensure that CD is successfully coped with by supporting CD sufferers to master every day life dilemmas through proper selfmanagement i.e learning to take control rather being controlled by food absorbing the entire

To date, nursing appears to be a neglected component of the follow-up of adults with CD. In fact it may add values to the care of adults with CD, knowing that in some countries only 60 per cent of patients have a high level of confidence in the information provided from a dietician or gastroenterologist. Even more so, 1,000 adult members of the German Celiac Society identified dissatisfaction with the doctor–patient communication as one of the

In our experience CD sufferers diagnosed in adulthood only rarely need monitoring of the diet adherence. Follow-up routines should rather focus on life adjustments, medical procedures to symptom control and measures to uncover depression signs preferably managed by a dedicated

multi-disciplinary team as employed in the care of adults with other chronic disorders.

CD is a benign yet sometimes a troublesome disorder of the GI tract often surrounded by obsolete patient's beliefs dated from the time of the diagnosis, making the condition especially hard to successfully cope with. This is apparently true for many women who are frustrated find the outcome of the long-term treatment and self-management worse than expected at start. The complexity of living with CD and remain well extends far beyond keeping the mucosa free from signs of inflammation. Given the increasing prevalence of CD across the globe improving the long-term health of these people represents a major challenge for any health care provider.

#### **8. References**


Högberg, L. Fälth-Magnussion, K. & Laurin, P. (2004). Oats to children with newly

Ludvigsson, JF. Reutfors, J. & Ösby, U. (2007). Coeliac disease and risk of mood disorders *J* 

Midhagen, G. & Hallert, C. (2003). High rate of gastrointestinal symptoms in celiac patients living on a gluten-free diet: controlled study. *Am J Gastroenterol*, Vol 98, 2023-26. Ring Jacobsson, L. Friedrichsen, M. & Göransson, A. (2011). Does a Coeliac school increase

Roos S. Wilhelmsson, S. & Hallert C. (2011). Well-being, self-image and bowel symptoms in

Roos, S. Kärner, A. & Hallert, C. (2006) Psychological well-being of adult coeliac patients

Roos, S. Wilhelmsson, S. & Hallert C. (2011). Swedish women with coeliac disease in

Roos, S. Wilhelmsson, S. & Hallert, C. (2011). Women with coeliac disease living on a gluten-

Stjernman, H. (2011). Crohn's disease in sickness and in health. MD *Thesis No.1228 Linkoping* 

Sverker, A. Hensing, G. & Hallert, C. (2005)'Controlled by food' – Lived experiences of

treated for 10 years. *Dig Liv Dis* Vol 38, pp.77-82.

coeliac disease. *J Hum Nutr Dietet* Vol 18, pp.171-80.

Scand J of Gastroenterol, Vol 46,pp 13-19.

*Gastroenterol* Vol 46, pp.13-19.

*University, Linkoping*, Sweden.

54.

*Affect Disord,* Vol 99, pp.117– 26.

*Nursing* (in press)

illness. (in press)

diagnosed coeliac disease: a randomized double blind study. *Gut,* Vol 53, pp.649-

psychological well-being in coeliac women living on a gluten-free diet? *J Clin* 

women with long-standing coeliac disease J of Nursing and Health care of Chronic

remission use more health care services than other women: a controlled study

free diet for years use more health-care than other Swedish women. *Scand J* 

### *Edited by Peter Kruzliak and Govind Bhagat*

Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye and barley) in genetically susceptible individuals. CD can manifest itself with a previously unappreciated range of clinical presentations, including the typical malabsorption syndrome and a spectrum of symptoms potentially affecting any organ system. Since CD often presents in an atypical or even silent manner, many cases remain undiagnosed and carry the risk of long-term complications, including anemia and other hematological complications, osteoporosis, neurological complications or cancer. The high prevalence of the disease and its variety of clinical outcomes raise several interesting questions. This book covers most of the aforementioned controversial and yet unresolved topics by including the contributions of experts in CD.What the reader will surely find stimulating about this book is not only its exhaustive coverage of our current knowledge of CD, but also provocative new concepts in disease pathogenesis and treatment.

Celiac Disease - From Pathophysiology to Advanced Therapies

Celiac Disease

From Pathophysiology

to Advanced Therapies

*Edited by Peter Kruzliak and Govind Bhagat*

Photo by Muenz / iStock