**2. 18β-Glycyrrhetinic acid (GRA)**

18β-Glycyrrhetinic acid (GRA), a pentacyclic triterpene derivative of the β-amyrin type, is obtained from the roots of *Glycyrrhizza glabra* L. It is known to exhibit a variety of pharmacological effects like antiulcerative, anti-hepatotoxic, anti-tumorigenic and immunoregulatory activities [14–17]. As evident, GRA has potent immunomodulatory effects, thus its potency as an antileishmanial agent and the underlying mechanism was thoroughly explored.
