Preface

Chapter 8 **Low-Dose Radiotherapy of Painful Heel Spur/Plantar Fasciitis**

Chapter 9 **Predictive Solution for Radiation Toxicity Based on**

Wenyong Tan, Xianming Li and Yong Dai

Chapter 11 **Radiotherapy Dose Optimization in Target Tissues Using**

Chapter 12 **Application of pMOS Dosimeters in Radiotherapy 231** Momčilo M. Pejović and Milić M. Pejović

Chapter 13 **A Comparison of Physical vs. Nonphysical Wedge Modalities in**

Chapter 14 **Motion Challenge of Thoracic Tumors at Radiotherapy by**

**Introducing an Available Compensation Strategy 263** Ahmad Esmaili Torshabi and Seyed Amir Reza Dastyar

Chapter 10 **Radiation-Related Heart Disease: Up-to-Date**

Cao, Kyung Hwan Chang and Chul Yong Kim

**Section 2 Side Effects 173**

**VI** Contents

**Big Data 175**

**Section 3 Physical Parameters 211**

**Developments 193**

Joseph John Bevelacqua

**Radiotherapy 251**

and Ryohei Sasaki

**as an Example of Treatment Effects in Benign Diseases 143** Robert Michael Hermann, Frank Bruns and Mirko Nitsche

Suk Lee, Kwang Hyeon Kim, Choi Suk Woo, Jang Bo Shim, Yuan Jie

**Internal Radiation-Generating Devices and Microspheres 213**

Hiroaki Akasaka, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Ryuichi Yada, Yasuyuki Shimizu, Saki Osuga, Yuki Wakahara

It is my pleasure to present the book entitled *Radiotherapy*. This book meets the experience of several researchers who dedicate many hours a day to not only treat patients but also assess the physical aspects of newer radiotherapy facilities.

This book comprises both clinical and physical aspects of radiotherapy modalities. Radio‐ therapy plays a key role in the treatment of many cancer types. Almost two-thirds of all can‐ cer patients receive some form of radiation therapy during the course of treatment, predominantly with external beam photon therapy. There are three major aspects of radio‐ therapy delivery strategies: definitive radiotherapy, adjuvant radiotherapy (either with or without concurrent chemotherapy), and neoadjuvant radiotherapy (either with or without concurrent chemotherapy). Highly conformal techniques such as intensity-modulated radio‐ therapy with image guidance allow precise delivery of higher doses of radiation within the target volume. With increasing technical advances, higher doses per fraction are used for both first-line treatment and re-irradiation for many tumor types, which have a potential to increase local control and survival in most cases. Advances in radiation therapy have con‐ tributed to improvements in long-term outcomes for cancer patients. For example, a 5-year survival of cancer has increased to approximately 68% in adults and 83% in children.

The book is divided into three sections with 14 chapters. The first section encompasses new treatment strategies for bone metastasis, lung cancer, and gynecological tumors. Two hot topics, re-irradiation in head and neck cancer and clinical outcomes of simultaneous inte‐ grated boost technique, which changes the current practice, are depicted with clinical stud‐ ies. Treatment outcomes of a rare entity—heel spur irradiation—are also discussed in detail. Long-term survivors are at increased risk to develop treatment-induced side effects, such as radiogenic second cancer, complications of the cardiovascular and central nervous systems, fertility problems, and other toxicities. In other sections, the late effects of radiotherapy are discussed. In the last section, physical parameters of new radiotherapy techniques are dis‐ cussed in detail.

This book is intended to bring forward the many advancements in the field of radiation on‐ cology. There are many valuable contributions from radiation oncology physicians and medical physicists who are experts in their fields. I would like to thank all contributors for their kind efforts in preparation of this book.

> **Cem Onal MD** Professor Baskent University Faculty of Medicine Dr. Turgut Noyan Research and Treatment Center Adana, Turkey

**Section 1**
