**3. Conclusions**

Reirradiation therapy is suitable and safe method of treatment for patients diagnosed with head and neck cancer relapse. It is important to take into consideration the functional status of the patient, recurrence location and volume, and time interval between initial radiotherapy and reirradiation. Surgical treatment, chemotherapy or biological therapies are more efficient methods of treatment when combined with reirradiation. Currently there is a lack of randomized clinical trials comparing effectiveness and toxicity of different radiotherapy methods, so for each case the potential of reirradiation therapy must be evaluated individually, considering recommendations presented here.
