**Acknowledgements**

Portions of this chapter are reproduced from the author's recent publication [54]. These studies were supported in part by grants from the National Institute of Health grants (HL-56973, HL-51952, HD084227, HD-047584, and HD-017644) and the American Heart Association (AHA-151521 and AHA-355741). An unrestricted grant from the Farley-Hudson Foundation (Jacksonville, NC), Groskert Heart Fund, and the Wake Forest Venture Fund is also acknowledged.
