**2. Pain treatment**

In the last decades, the understanding of the multiple mechanisms and molecules that underlie pain perception have turned its treatment into a puzzle formed by therapies that involve not only the common substances considered as analgesics (NSAIDS and opioids) but also a wide array of other drugs such as anticonvulsants and antidepressant and not less important manual techniques, together with psychological follow-up, which has also proved to be successful in containing patients emotionally [10, 12–14]. The understanding of the different routes involved in this complex phenomenon has opened its therapy not only to drugs, not previously considered as analgesics, but also to the development of pharmaceutical forms able to alleviate pain for long periods of time as well as electrical techniques for the interruption of pain signal transduction [13, 14, 17].

Even though medicines seem to be the most common resource for pain relief, and despite all the advances in pain understanding, many people still restore to nontraditional or alternative medicine, some forced by the high costs of health care and others pushed by the inefficacy of conventional treatments [18].
