**2.1. Acetaminophen**

Acetaminophen (paracetamol) is a common medication to treat fever and pain [11]; this medicine is mostly used for slight and moderate body pain. On the other hand, paracetamol in combination with opioid are used for severe pain, such as pain after surgery [12]. Acetaminophen is used orally or taken intravenously [12] and its effect lasts between 2 and 4 hours. Acetaminophen is classified as slight analgesic [13] and is harmless at the recom‐ mended doses [13, 14].

## **2.2. NSAIDs as analgesics drug**

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are a class of medications that provide anti‐ pyretic and analgesic effects, and in higher doses have anti‐inflammatory potential. They are among the most commonly used analgesics for arthritic pain worldwide. The prominent members of this group of drugs are ibuprofen, aspirin, and naproxen, which are available and used in most countries [15]. Analgesic NSAIDs are nonnarcotic and are used as a nonaddic‐ tive alternate to narcotics.
