**4. Conclusion**

Patient‐controlled analgesia (PCA) is a great option for acute pain control. Several advantages of this technique can be highlighted, such as higher analgesic standard with patient's satisfac‐ tion, and also minor side effects. However, there is still no consensus regarding which is the best route or drug used since clinical efficacy/safety depends on the complex comprehension of the pharmacokinetic drugs profile through different routes of administration. Additionally, pharmacoeconomic studies are needed to evaluate the cost‐effectiveness of these approaches.
