**Author details**

investigation to provide an overall view of the action of paracetamol. The understanding of the neurological and molecular actions of clinically used analgesics such as paracetamol

 **Figure 4.** Proposed sequential mechanisms for the antinociceptive effect of paracetamol. (1) Deacetylation of paracetamol in *p*-aminophenol in the liver. (2) FAAH-dependent metabolism of *p*-aminophenol into AM404 in the brain. (3) Direct

bulbospinal pathways and (5) Involvement of spinal pain-suppressing serotonergic receptors. © Frédérique Koulkoff/

receptors by this metabolite. (4) Reinforcement of the serotonergic

and/or indirect involvement of supra-spinal CB1

Inserm from Mallet/UMR 1107/Neuro-Dol Inserm.

could pave the way for the discovery of new analgesic compounds.

216 Pain Relief - From Analgesics to Alternative Therapies

Christophe Mallet1,2\*, Alain Eschalier1,2,3 and Laurence Daulhac1,2

\*Address all correspondence to: christophe.mallet@udamail.fr

1 University of Clermont Auvergne, Fundamental and Clinical Pharmacology of Pain, Clermont-Ferrand, France

2 Inserm U 1107, Neuro-Dol, Clermont-Ferrand, France

3 CHU Clermont-Ferrand, Department of Pharmacology, Clermont-Ferrand, France
