**4.2. Selective serotonin reuptake inhibitors**

The SSRIs are not so effective in treating pain. They can be considered as first‐line agents when treatment of the depression is the priority, if TCAs are contraindicated or venlafaxine has failed. When using SSRIs, it is important to be aware of the metabolism in the liver by cyto‐ chrome P450 isoenzymes and potential interactions as most of them are enzymes inhibitors. Citalopram and escitalopram have the least impact on the cytochrome P450 isoenzymes [3, 39].
