**Regulation of the Renin-Angiotensin-Aldosterone System by Reactive Oxygen Species**

Manuela Morato, Marta Reina-Couto, Dora Pinho, António Albino-Teixeira and Teresa Sousa

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/67016

### Abstract

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118 Renin-Angiotensin System - Past, Present and Future

Molecular Therapy. 2014;**22**:2069-2082.

Angiotensin II (Ang II), the major effector of the renin-angiotensin-aldosterone system (RAAS), stimulates the production of reactive oxygen species (ROS) which are critically involved in Ang II-induced effects. Noteworthy, accumulating evidence indicates that ROS also regulate the activation of RAAS, contributing to the fine-tuning of this system under physiological conditions or to the amplification of the deleterious signaling in several pathologies. This chapter aims at giving an overview of the role of ROS in the regulation of expression, secretion and/or activity of several RAAS components.

Keywords: reactive oxygen species, superoxide, hydrogen peroxide, angiotensinogen, renin, pro(renin) receptor, angiotensin converting enzyme, angiotensin converting enzyme-2, angiotensin II, angiotensin 1–7, aldosterone, angiotensin II type 1 (AT1) receptor, angiotensin II type 2 (AT2) receptor, MAS receptor, regulation of expression, secretion or activity
