**Acknowledgements**

after Goldblatt' successfully raised blood pressure by inducing renal ischemia in dogs, the Regional Conference on Basic Mechanisms of Arterial Hypertension of the University of Michigan was held in Ann Arbor in his honor. The Organizing Committee was chaired by Drs Sibley W. Hoobler and David F. Bohr [15]. It was then that, beyond and far from conflict, Braun‐Menéndez and Page agreed on a new nomenclature. As the result, the words angioten‐ sinogen and angiotensin were born from the combination of the names originally set by both

Edward D. Frohlich (Alton Ochsner Distinguished Scientist at the Alton Ochsner Medical Foundation and Editor in Chief of the *Hypertension* journal) commented that Page had pointed out to him, while he was drinking martinis with Braun‐Menéndez at a lunch during the Michigan meeting. It was by then that the compromised to solve the differences getting to a common nomenclature for their findings. Then, a very short and concise report was published in Science and was the very proof of their settled agreement [1, 36]. Actually, as Page recog‐ nized, cooperation was so close that claiming priority from any part would have been non‐ sense and they should share either the blame of the congratulations [32]. In 1985, Page sent a letter to Fasciolo expressing his hope that their resolve on the nomenclature issue would serve as an example for future generations of scientists to come. He shared an interesting message for the future generations of scientists saying that they could not possibly leave unsolved a his‐ torical puzzle so anyone might speculate on an imaginary dispute which had never occurred. In his letter, he clearly stated that the hypertension story should well serve as a model to follow when dealing with difficult situations, for example, with gentleness and making alliances [23]. The following years were strange, in the sense that Goldblatt and Skeggs in the United States, and leading groups in Europe went on using the Argentine name [15]. In contrast, Taquini et al. emphasized on the need of accepting unified names [37]. In one of his publications, Leonard T. Skeggs Jr. (1918–2002, biochemist in Case Western Reserve University, Cleveland, Ohio) mentioned: "I must explain, parenthetically that angiotensin was known to us, being follow‐ ers of Harry Goldblatt and Eduardo Braun‐Menéndez, as hypertension. Merlin Bumpus knew angiotensin as angiotonin. This was natural because Merlin worked with Irvine Page, who had coined the name angiotonin. It was a number of years later that Page and Braun‐Menéndez

agreed on the name angiotensin, and all the rest of us used the new name" [38].

proposed earlier by Page et al. showing no convincing evidence though [43].

they were essentially remarkable persons.

**2.5. What comes after this great discovery**

Both teams shared the merit of the discovery, proving that beyond being great investigators

Following angiotensin discovery, the Argentine team focused on studying the enzymatic origin and release of angiotensin from angiotensinogen, the peptidic nature of angiotensin, renin secretion from kidneys, hepatic synthesis of angiotensinogen, pharmacological profile of angiotensin, and so [39–41]. Researchers like Alberto Agrest, Pedro C. Blaquier, Alberto C. Taquini, Jr and Ignacio J. de la Riva, who had begun their scientific career working at the *Instituto de Investigaciones Cardiológicas* (School of Medicine, University of Buenos Aires) years ago, returned to work there [15]. Leloir et al. conclusively confirmed the hepatic origin of renin studying nephrectomized dogs with and without liver ablation [42]. This had been

teams [32, 36].

8 Renin-Angiotensin System - Past, Present and Future

The authors thank Melisa Etchegoyen and Francisco Báez for helping with proof reading and language correction.
