**Acknowledgements**

The work was supported by the Spanish Ministry of Science and Innovation (CGL2011-26252 and BFU2011-25455), the Basque Government (Spain) (research project IT376-10, grants BFI-2011-85 to C. Parada), and the Basque Foundation for Science, Ikerbasque (Spain). Proteomic analyses were performed at the Proteomics Unit at the University of the Basque Country, UPV/EHU, Spain (SGIker, member of ProteoRed).

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