**17.2 Dual inhibitors of endothelin converting enzyme and neutral endopeptidase**

Endothelin produced by endothelin converting enzyme (ECE) is a potent vasoconstrictor and profibrotic agent, while natriuretic peptides are degraded by NEP which have diuretic, vasodilator and antifibrotic properties, so that in a combination same drug of these actions could have a beneficial effect on cardiovascular remodelling, control of BP and cardiovascular mortality. Recently, several drugs have been synthesized: CGS 26303, CGS 34226, SLV88, SLV306 and SLV388, with which promising effects in experimental animals on cardiovascular hemodynamic independently of the BP have been shown. (Dhaun & Webb., 2011) That is why pre-clinical and clinical studies will be the future stage in these novel drugs.
