**3. Causes**

HME is mainly caused by HSV type 1, type 2 or as secondary squeal of other diseases like Crohn's disease [2, 6]. HME accounts for about 10% of the total meningoencephalitis cases with a effecting rate of about 2/10<sup>6</sup> . Most of the HME cases are seen in case of infants or children. The infection is contaminated through coughing, sneezing or close contact. Type 1 viruses can spread through food, water, and air, whereas type 2 transmits mainly through sexual contact [3]. Sometimes, after complete treatment, also the viruses remain silently in the body and relapse at a later stage. AIDS, alcoholism, diabetes, immunosuppressant drugs, splenectomy, and other immunosuppressive factors increase the susceptibility of a person toward getting infected. The infection may cause partial or complete impairment of the brain or sensory organs, kidney failure or death [7]. Therefore, there is a compulsory need for an early diagnosis of the disease followed by treatment.
