**7. Conclusions**

HME is one of the most dreadful forms of aseptic meningoencephalitis caused by HSV 1 and 2. It has a high mortality and morbidity rate especially in infants. The fail to accurate diagnosis and complete treatment has raised the risk of disease. Therefore, a rapid and accurate diagnosis is essential for early treatment of the infection and effective public health management. The inefficacy for eradication of any disease is equally shared by ignorance of the people and fail of early treatment. Therefore, the dreadful impact of this disease should be made aware to the common people. Recent advances in the field of diagnosis such as PCR, microarray, and nanosensors may help for early diagnosis. Still, there is a high demand on the research regarding early treatment of the infection to save the life of people.
