**2. Symptoms**

The symptoms of HME resemble to common flu and may vary among children, adults, and neonates. HME type 1 is more prominent at age below 20 years or over 40 years. The earlier symptoms shown in children and adults are fever, disorientation, or speech problem. At a later stage, headache, vomiting, fever, drowsiness, seizures, and unconsciousness also appear. Specific symptoms of this infection are nuchal rigidity, blurred vision, hallucinations, purple rashes or behavioral changes [4]. Infants are mainly infected by type 2, and the symptoms include high fever, bulging of forehead, poor feeding or constant sleepiness.
