**2.3. Aurora-C**

The Aurora-C is encoded by the *AURKC* gene localized at chromosome 19q13.43 and consisting of seven exons (Gene ID: 6795). The *AURKC* promoter is much less characterized with respect to those of Aurora-A and Aurora-B. A CCAAT box is present at −36 to −23 (Eukaryotic Promoter Database, Swiss Institute of Bioinformatics). *AURKC* promoter activity has been shown to be downregulated by the transcription factor PLZF [56]. The 1.3 kb transcript encodes a protein of 309 amino acids with a predicted molecular mass of 35.6 kDa (**Figure 1**) [39]. Different from Aurora-A and Aurora-B, Aurora-C does not contain the KEN and the A box/DAD motifs in its N-terminal region, while the C-terminal D box is present. The mechanism(s) underlying its degradation, however, still remains to be elucidated.
