**6. Mechanism of action**

The biological targets and SHetA2's mechanism of action have been extensively studied. Coimmunoprecipitation experiments demonstrated that SHetA2 interfered with the binding of mortalin, a molecular chaperone to p53 and p66 Src homologous-collagen homolog (p66shc) in A2780 ovarian cancer cell line, leading to mitochondrial swelling and mitophagy and finally apoptosis [8]. SHetA2 is also involved in modulating other cellular processes including cellgrowth, differentiation, and angiogenesis.
